Researchers find a common weakness in major gut pathogens (Links to an external site)

WashU Medicine researchers and collaborators at the University of Missouri identified a shared vulnerability across diarrhea-causing bacteria including E. coli (shown) and Shigella, a finding that could potentially lead to a single combination vaccine against these pathogens.

The bacteria enterotoxigenic E. coli and Shigella together cause hundreds of millions of infections each year and are among the leading causes of diarrheal death, especially in children. Decades of vaccine development efforts have come up short, in part because the usual vaccine targets vary too much from one strain to the next.

How obesity disrupts the body’s cellular messaging system (Links to an external site)

Clair Crewe, PhD

Lead author Clair Crewe, PhD, Assistant Professor of Medicine in WashU Medicine’s Division of Cell Biology and Physiology and Division of Endocrinology, Metabolism and Lipid Research, the Crewe Lab and collaborators from the Department of Pathology and Immunology and the Center for Human Nutrition are authors of a study published May 5, 2026, in Cell Metabolism.

Dr. Will Ross Receives NKF Award of Excellence (Links to an external site)

Will Ross, MD

Congratulations to Will Ross, MD, MPH, Alumni Endowed Professor of Medicine, Nephrology, and Associate Dean for Diversity at Washington University School of Medicine, who was honored with the National Kidney Foundation’s (NKF) Award of Excellence at their 75th Anniversary Heroes Awards celebration on March 5, 2026.  

Ignacio Portales-Castillo Awarded OKRA Opportunity Program Grant (Links to an external site)

Ignacio Portales-Castillo, MD, Assistant Professor of Medicine

Ignacio Portales‑Castillo, MD, assistant professor of medicine in the Division of Nephrology, has been selected for funding in the third round of the George M. O’Brien Kidney Resource Alliance (OKRA) Opportunity Pool Program. He will receive $50,000 in research support for his pilot grant proposal, “Reduce Creatine in Proximal Tubule to Enhance Autophagy and Protect from Renal Injury.” 

May 2026 Kudos and Awards

Thank you, residents and interns, for all you do for one another and for your patients. Though often under-appreciated, your work does not go unnoticed. ​​​​​​​Help us highlight the kindness, clinical skills, and work ethic: submit here. Resident of the Month Dr. John Davis: “He was an absolutely remarkable senior to have on firm. He has incredible clinical […]

Genetically modified hookworms produce and deliver therapeutics (Links to an external site)

WashU Medicine researchers genetically modified hookworms to produce and deliver a therapeutic antibody inside a host, a proof-of-concept that could lead to long-lasting treatments for chronic disease or exposure to toxins in remote settings. (Image courtesy of Makedonka Mitreva)

Hookworms, intestinal parasites that infect hundreds of millions of people in under-resourced tropical regions around the globe, have evolved to survive inside the human gut for years, secreting molecules that enable co-existence with their hosts. Now, researchers at Washington University School of Medicine in St. Louis have harnessed that biological mechanism for potential human benefit, […]

Millman receives grant to advance cell therapies for type 1 diabetes  (Links to an external site)

Jeffrey Millman, PhD

Jeffrey R. Millman, PhD, Professor of Medicine in the Division of Endocrinology, Metabolism & Lipid Research at WashU Medicine, has received research funding from Breakthrough T1D to support his project titled “Overcoming Production Barriers to Stem Cell-Islet Therapies Through Scalable Technologies.” The two-year grant supports efforts to address key challenges in bringing manufactured islet cell therapies for type […]

WashU Medicine researcher advances understanding of emerging tick-borne threats in the Midwest

At WashU Medicine, virologist Jacco Boon, PhD, Division of Infectious Diseases, is turning his attention to a growing but often overlooked public health concern: tick-borne viruses in Missouri and across the Midwest. Boon’s path to studying some of the world’s smallest—and most complex—infectious agents began long before his work in Missouri. Originally from the Netherlands, […]

Phoenix Molecular Designs Expands PMD-026 into Second Clinical Indication with Myelofibrosis Trial at WashU Medicine (Links to an external site)

Amy Zhou, MD, a hematologist at Washington University School of Medicine in St. Louis, sees a patient at Siteman Cancer Center's West County facility in Creve Coeur. Zhou treats patients with various blood disorders and conducts clinical trials investigating possible new therapies for such patients.

SAN DIEGO, California – VANCOUVER, British Columbia, May 27, 2026 – Phoenix Molecular Designs (PhoenixMD), a clinical-stage precision oncology company developing first-in-class RSK kinase inhibitors, today announced the expansion of its lead asset PMD-026 into a second clinical indication with the initiation of Dauntless-3, an investigator-initiated Phase 1 trial in myelofibrosis at Washington University School […]

Zhiyu Dai, PhD, Receives 2026 Werner Risau Early Career Investigator Award in Vascular Biology (Links to an external site)

Zhiyu Dai, PhD, Associate Professor of Medicine

Congratulations to Zhiyu Dai, PhD, Associate Professor of Medicine, who was selected for the 2026 Werner Risau Early Career Investigator Award in Vascular Biology. This distinguished award was established in honor of Dr. Werner Risau, an investigator who formulated key concepts for the regulation of angiogenesis, challenged the prevailing dogmas about angiogenic factors, and proposed […]

Dr. Anuja Java Highlights Complement‑Mediated Kidney Disease at ISN’s 2026 World Congress of Nephrology in Yokohama (Links to an external site)

Anuja Java, MD

Transplant nephrologist Anuja Java, MD, associate professor of medicine at WashU Nephrology and Director of Kidney Transplant at the John Cochran VA Medical Center, was invited for the third consecutive year to speak at the International Society of Nephrology’s World Congress of Nephrology (WCN’26), held this year, March 28–31, 2026, in Yokohama, Japan.

Researchers augment infection surveillance tool with AI, find enhanced patient safety (Links to an external site)

Abby Sung, MD

WashU Medicine infectious diseases researchers have developed a practical use of artificial intelligence to enhance patient safety, while potentially reducing costs and improving efficiency at hospitals. Abby Sung, MD, an assistant professor of medicine, and colleagues in the Division of Infectious Diseases, WashU McKelvey School of Engineering AI for Health Institute, and Barnes-Jewish Hospital (BJH) found that a large language model (LLM) can strengthen a semi-automated surveillance tool used by infection prevention. 

Celebrating our 2025-2026 Graduates and Award Recipients (Links to an external site)

CRTC graduates and faculty

Throughout the academic year, scholars work relentlessly to elevate their learning and support their peers, mentors show up day after day ready to provide guidance to their mentees, and course directors engage scholars in labs and classrooms with dynamic training. This strong community is central to the success of programs at WashU Medicine, and it […]

Fan He Receives Evans MDS Young Investigator Award

Grant will support innovate research on inflammation and myelodysplastic syndrome (MDS) Fan He, PhD, Instructor in Medicine, Department of Medicine, Division of Hematology, has been awarded a Young Investigator Award (YIA) from the Edward P. Evans Foundation to support innovative research investigating inflammatory mechanisms that drive myelodysplastic syndromes (MDS). MDS is characterized by ineffective blood […]

Faculty join Infectious Diseases Society of America Fellowship in 2026 (Links to an external site)

Faculty join Infectious Diseases Society of America Fellowship in 2026

Nicolo Cabrera, MD, Joseph Cherabie, MD, MSc, and Adriana Rauseo, MD, Assistant Professors of Medicine, and Aaloke Mody, MD, Associate Professor in Medicine, have joined more than a dozen other Washington University School of Medicine Division of Infectious Diseases faculty members as Fellows of the Infectious Diseases Society of America (IDSA). They are among 166 new fellows this year to receive […]

Class Acts 2026: Ariel Hernandez-Leyva (Links to an external site)

Ariel Hernandez-Leyva, a graduating MD/PhD student at WashU Medicine

For about an hour, Ariel Hernandez-Leyva held a scientific secret. A discovery only he had uncovered. At the time, more than a decade ago, he was an undergraduate at Yale University, working long hours in a biology lab studying cytokinesis, the final stage of cell division. One spring afternoon, while using a high-resolution fluorescence microscope […]

Goldberg co-authors study on obicetrapib in patients with heterozygous familial hypercholesterolemia (Links to an external site)

Anne Carol Goldberg, MD, FACP, Professor of Medicine in the Division of Endocrinology, Metabolism & Lipid Research

Anne Carol Goldberg, MD, FACP, Professor of Medicine in the Division of Endocrinology, Metabolism & Lipid Research at WashU Medicine, is a co-author of a study published February 27, 2026, in Nature Medicine. The article, titled “Obicetrapib in patients with heterozygous familial hypercholesterolemia: the BROOKLYN randomized clinical trial,” explores a potential new option for people living […]

Soudah and collaborators review semaglutide’s metabolic and cognitive effects  (Links to an external site)

Hani Soudah, MD, PhD

On March 1, Hani Soudah, MD, PhD, Associate Professor of Medicine in the Division of Endocrinology, Metabolism, & Lipid Research at WashU Medicine, along with collaborators, published a new systematic review and meta-analysis examining the broader physiological effects of semaglutide titled “A Systematic Review and Meta-Analysis of Semaglutide Effects on Adipose Tissue and Emerging Effects on Brain and Cognition.” 

Identifying how the body regulates fat breakdown during metabolic stress (Links to an external site)

Irfan Lodhi, PhD, Professor of Medicine in the Division of Endocrinology, Metabolism & Lipid Research at WashU Medicine

Irfan Lodhi, PhD, Professor of Medicine in the Division of Endocrinology, Metabolism & Lipid Research at WashU Medicine, and collaborators are authors of a study published January 8, 2026, in Nature Metabolism. The article, titled “A catecholamine-independent pathway controlling adaptive adipocyte lipolysis,” investigates how the body breaks down stable fat stores during conditions such as starvation, wasting and cachexia. 

Dr. Tyler Parsons joins the Department of Medicine

Dr. Tyler Parsons joins the Department of Medicine in the Division of Oncology as an Instructor as of May 2026. Dr. Tyler Parsons completed his PhD at Oakland University and the Beaumont Research Institute in the Department of Radiation Oncology where he discovered that hematopoietic stem and progenitor cells (HSPCs) migrate to solid tumors after […]

WashU Celebration of Inventors 2026 (Links to an external site)

WashU Celebration of Inventors 2026

On May 7, 2026, the Office of Technology Management hosted the ninth annual Celebration of Inventors, an event to honor and recognize Washington University inventors, researchers and faculty entrepreneurs. Honorees included 2025 United States Patent and Trademark Office (USPTO) awardees; newly elected National Academy of Inventors Fellows and Senior Members; and the recipients of the 2026 […]

April 2026 Kudos and Awards

Thank you, residents and interns, for all you do for one another and for your patients. Though often under-appreciated, your work does not go unnoticed. ​​​​​​​Help us highlight the kindness, clinical skills, and work ethic: submit here. Residents of the Month Dr. Antara Dattagupta: “Despite already being a phenomenal resident, she displayed an unwavering commitment to personal growth, soliciting […]

Jennifer Alexander-Brett, MD, PhD Featured for COPD Research Advances (Links to an external site)

Jennifer Alexander-Brett, MD, PhD

Jennifer Alexander‑Brett, MD, PhD, Associate Professor of Medicine, has been featured in a recent Nature Biotechnology article highlighting major advances in targeting interleukin‑33 (IL‑33) signaling in chronic obstructive pulmonary disease (COPD). The article, “Newcomer anti‑IL‑33 makes strides in COPD,” underscores the growing impact of IL‑33–focused therapeutics and the importance of foundational biological insight in translating discovery to patient […]

Personalized vaccine shows promise against aggressive brain cancer (Links to an external site)

A WashU Medicine-led clinical trial conducted at Siteman Cancer Center has found that a personalized vaccine to treat glioblastoma is safe and could potentially improve outcomes. Trial participant Kim Garland (left) reviews a scan with the study’s primary investigator, Tanner Johanns, MD, PhD, a WashU Medicine oncologist.

A personalized vaccine to treat glioblastoma, a fast-growing and incurable brain cancer that affects four in 100,000 people in the U.S., is safe and elicits robust and broad immune responses that appears to increase recurrence-free survival in a subset of patients after surgery, according to an early-stage clinical trial co-led by researchers at Washington University […]

2026 Spring Cycle ICTS NIH Mock Study Section Recap (Links to an external site)

Wednesday, April 15, 2026, marks the 15th spring cycle of the ICTS NIH Mock Study Section. Through its Research Development Program, the ICTS offers NIH Mock Study Sections (MSS) that closely simulate an actual NIH study section. These sessions provide detailed, study section–style feedback on complete grant applications for clinical and translational R, K, and […]

People with poor mental health report worse care worldwide (Links to an external site)

A global study of more than 32,000 adults in 18 countries finds that people with poor mental health experience more unmet needs and lower confidence in care. (Photo: Getty Images)

A new multinational study finds that individuals with poor mental health consistently report lower-quality healthcare experiences across diverse health systems. Published May 5 in PLOS Medicine, the study was led by Margaret E. Kruk, MD, of Washington University School of Medicine in St. Louis, in collaboration with an international team of researchers.

AGA Awards Cao 2026 Pilot Research Award

Siyan "Stewart" Cao, MD, PhD

Provides support for research on perianal fistulizing Crohn’s disease (PFCD) Siyan “Stewart” Cao, MD, PhD, Assistant Professor, WashU Medicine Division of Gastroenterology, recently was awarded the 2026 American Gastroenterological Association Pilot Research Award. The AGA Research Foundation Pilot Research Award was presented to fifteen distinguished clinical researchers, providing funding to support early-career investigators in establishing their […]

Renowned Gastroenterology Leader at Siteman Cancer Center Honored for Mentorship (Links to an external site)

Nicholas Davidson, MD

Nicholas O. Davidson, MD, DSc, AGAF, the John E. and Adaline Simon Professor of Medicine and Developmental Biology and chief of the Division of Gastroenterology at WashU Medicine and a nationally recognized physician-scientist who treats patients at Siteman Cancer Center at Barnes-Jewish Hospital and WashU Medicine, is the recipient of the 2026 Distinguished Mentor Award from the American Gastroenterological Association (AGA). He will […]

Davis Receives 2025 JACC: Heart Failure Top Reviewer Award

John Davis, MD, PhD

John W. Davis, MD, PhD, Resident, WashU Medicine Department Medicine, has been selected for a JACC: Heart Failure Top Peer Reviewer Award. The award was presented at the American College of Cardiology’s Annual Scientific Session (ACC.26) in New Orleans, recognizing outstanding peer reviewers for the journal during the past year. Davis is one of 20 […]

ICTS Announces 2026-2027 PDSS Awardees (Links to an external site)

Congratulations to Karla Washington, PhD, LCSW, Associate Professor of Medicine who was one of the awardees. The Center for Community Health Partnership and Research is pleased to announce four partnerships were selected to receive 2026-2027 Partnership Development and Sustainability Support (PDSS) funding. These awards provide up to $10,000 in funding over a 12-month period for investigators […]