Once a freak occurrence, fungi resistant to standard drugs now threaten millions of vulnerable Americans It took doctors a month to figure out a fungus had infected Glenda Brame’s bloodstream. The delay likely led to her death. The 56-year-old died in September, felled by a fungus that kills between 30% and 60% of people it […]
Studies in mice and in human immune cells link low prenatal vitamin D in mothers to insulin resistance in offspring Researchers at Washington University School of Medicine in St. Louis have identified a process in immune cells that links vitamin D deficiency during pregnancy to an increased risk of Type 2 diabetes in offspring. The […]
The association of donor hepatitis C virus infection with 3-year kidney transplant outcomes in the era of direct-acting antiviral medications Tarek Alhamad, MD, MS, MBA, Associate Professor of Medicine, Medical Director of Transplant Nephrology, Division of Nephrology, recently had two manuscripts published in JAMA Open and the American Journal of Transplantation regarding new findings of […]
Primary cilia are vital cell-surface sensory organelles, but their physical dimensions have eluded characterization due to difficulty in isolating and studying these enigmatic structures, especially in human tissues. In the present study, we use a multi-scale surface scanning approach to enable a 3D architectural study of human primary cilia, the first in pancreatic islets and […]
Diabetes researchers at Washington University School of Medicine in St. Louis have uncovered at least one reason insulin-secreting cells made from stem cells in the lab don’t work as well as natural cells. The discovery could help speed progress toward making insulin-secreting cells — called islet beta cells — more effective in the treatment of […]
In April, Fumihiko Urano, MD, PhD was featured in the documentary “Colorado Voices: Ellie White,” to raise awareness of the rare genetic disorder, Wolfram syndrome. The short documentary was published by Rocky Mountain PBS and tells the story of Colorado college student Ellie White, who lives with the disorder. Although the disorder is very rare […]
Researchers at Washington University School of Medicine in St. Louis have identified four important signs and symptoms that signal an elevated risk of early-onset colorectal cancer. These red flags may be key to earlier detection and diagnosis of early-onset colorectal cancer among younger adults. The number of young adults with colorectal cancer has nearly doubled […]
Hrishikesh Kulkarni MD, MSCI, from the Division of Pulmonary and Critical Care Medicine recently had two manuscripts published in Science Immunology and a Phase 3 clinical Trial on complement inhibition in COVID-19 in the Lancet Respiratory Medicine. Lung epithelial cell–derived C3 protects against pneumonia-induced lung injury The complement cascade is made up of innate immune defense proteins that protect […]
Researchers at Washington University School of Medicine in St. Louis have received a grant from the National Institutes of Health (NIH) to support training and mentorship for early-career physician-scientists. This relatively new funding opportunity — called Stimulating Access to Research During Residency (StARR) — will provide support for early-career physicians pursuing careers in cancer research.
EMMI helps assess uterine contractions to aid in preventing preterm deliveries Dr. Phillip Cuculich, Cardiovascular Division at Washington University School of Medicine in St. Louis, shared new findings that were published in Nature Communication. The group of doctors led by Dr. Yong Wang, published the “first-in-woman” study blending the disciplines of cardiac electrophysiology and obstetrics. […]
SSCI Research Scholar Award Deadline – September 1Details and information on this $25,000 (plus 10% indirect costs) pilot funding award can be found at here. SRM 2023 Abstract Deadline – October 7Information on SRM 2023 and abstract submission will soon be available on our website. Abstract submission site will open August 1. SSCI Mentor of […]
As part of ‘All of Us’ research program, School of Medicine will seek to enroll local participants
Sugary beverage consumption in adolescence, young adulthood associated with increased risk
Further studies underway to determine extent of clinical benefits
Study indicates timing of chemotherapy could improve treatment for deadly brain cancer
Independent of cholesterol, gene variants raise risk of heart disease, diabetes, high blood pressure
Virus-based therapy may unlock potential of immunotherapy for glioblastoma
Sequencing results returned in a few days; costs similar to conventional testing
Findings could help explain how asthma, COPD, severe COVID-19 are triggered
Researchers seek participants with diabetes that doesn’t fit type 1 or type 2 categories
Study reveals details of how coronavirus infects heart; models of tissue damage may help develop potential therapies
Research involving cytokines and how they’re packaged sheds light on inflammation in asthma, COPD, COVID-19
Washington University researchers part of team probing inflammation after heart attack
Glioblastoma study could lead to new treatments, including better immunotherapies
New grant to fund research into drugs that showed promise in small study of people with Crohn’s disease
Drugs that trigger alarm could lead to new HIV therapies
Findings could help improve treatment decisions
Medical school labs pivot to fight a common enemy
2 drugs targeting cancer cells’ energy source potentially could replace toxic chemo in osteosarcoma
Mice expressing increased levels of protein develop advanced liver disease
Measuring mitochondrial DNA could predict who will need ICU care, intubation
Newly identified pathway explains why antihistamine drugs often don’t work to control severe itch
Bacteria change surface of human intestine to benefit themselves
Bacteria change surface of human intestine to benefit themselves
Discovery of receptor, generation of decoy could help contain outbreaks of Venezuelan equine encephalitis virus
New findings from researchers at Washington University School of Medicine in St. Louis suggest the eye’s cornea can resist infection from the novel coronavirus. Although the herpes simplex virus can infect the cornea and spread to other parts of the body in patients with compromised immune systems, and Zika virus has been found in tears […]
Washington University School of Medicine in St. Louis is a testing site for the Janssen Pharmaceutical Companies of Johnson & Johnson’s phase 3 clinical research study, called the ENSEMBLE trial, to evaluate the safety and efficacy of Janssen’s investigational COVID-19 vaccine candidate, JNJ-78436735, also known as Ad26.COV2.S.
One of the most vexing aspects of the COVID-19 pandemic is the novel coronavirus’s ability to turn the body’s immune system against the body. After the virus has been cleared from the body, the immune system sometimes continues to hurtle an arsenal of immune proteins at the already vanquished virus, creating a dangerous inflammatory response […]
The communities of bacteria that live in our digestive tracts help digest food and produce vitamins, protect against pathogens, and promote the healthy functioning of our immune system. But alongside gut bacteria thrives a vast community of viruses, and we know little about their impact on health and disease.
Flu season comes around like clockwork every year, and sooner or later everyone gets infected. The annual flu shot is a key part of public health efforts to control the flu, but the vaccine’s effectiveness is notoriously poor, falling somewhere from 40% to 60% in a typical year.
Flu season comes around like clockwork every year, and sooner or later everyone gets infected. The annual flu shot is a key part of public health efforts to control the flu, but the vaccine’s effectiveness is notoriously poor, falling somewhere from 40% to 60% in a typical year. A growing body of evidence suggests that […]
Scientists at Washington University School of Medicine in St. Louis have developed a vaccine that targets the SARS-CoV-2 virus, can be given in one dose via the nose and is effective in preventing infection in mice susceptible to the novel coronavirus. The investigators next plan to test the vaccine in nonhuman primates and humans to […]
Gastric bypass surgery is the most effective therapy to treat or reverse type 2 diabetes in severely obese patients. Many achieve remission of diabetes following surgery and no longer require diabetes medications. This observation has led to the theory that gastric bypass surgery has unique, weight loss-independent effects in treating diabetes, but this has remained […]
Researchers at Washington University School of Medicine in St. Louis are investigating whether a drug approved by the Food and Drug Administration (FDA) to treat rare diseases of an overactive immune system could help critically ill patients hospitalized with COVID-19. The drug blocks a specific protein of the immune system that doctors suspect contributes to […]
An experimental vaccine is effective at preventing pneumonia in mice infected with the COVID-19 virus, according to a study from Washington University School of Medicine in St. Louis. The vaccine, which is made from a mild virus genetically modified to carry a key gene from the COVID-19 virus, is described in the journal Cell Host […]
Washington University in St. Louis, the St. Louis County Department of Public Health and other collaborators are conducting a survey of St. Louis County residents and offering COVID-19 testing to gauge the prevalence of and risk factors for the illness. Working with the county, Washington University’s Institute for Public Health is teaming up with other local public health and […]
The virus that causes COVID-19 probably originated in wild bats that live in caves around Wuhan, China, and may have been passed to a second animal species before infecting people, according to the World Health Organization. Many of the most devastating epidemics of recent decades – including Ebola, avian influenza and HIV/AIDS – were triggered […]
Many children treated for childhood malnutrition in developing countries never fully recover. They suffer from stunted growth, immune system dysfunction and poor cognitive development that typically cause long-term health issues into adulthood.
Some of the most promising advances in cancer treatment have centered on immunotherapies that rev up a patient’s immune system to attack cancer. But immunotherapies don’t work in all patients, and researchers have been searching for ways to increase their effectiveness.