A new study published in the Journal of the American Medical Informatics Association (JAMIA) showcases how modern AI methods are advancing clinical and translational research in Neurofibromatosis type 1 (NF1). Conducted by Levi Kaster, BS, Ethan Hillis, MS, Inez Y. Oh, PhD, Elizabeth C. Cordell, MD, Randi E. Foraker, PhD, MA, Albert M. Lai, PhD, Stephanie M. Morris, […]
Hepatitis C, a bloodborne virus that damages the liver, can cause cirrhosis, liver cancer, liver failure and death if left untreated. Despite the availability of highly effective treatments, the prevalence of hepatitis C infection remains high, particularly among women of childbearing age, who account for more than one-fifth of chronic hepatitis C infections globally. Within […]
Malnutrition is a leading cause of death in children under age 5, and nearly 150 million children globally under this age have stunted growth from lack of nutrition. Although an inadequate diet is a major contributor, researchers at Washington University School of Medicine in St. Louis found over a decade ago that dysfunctional communities of gut […]
On August 4, The Washington Post published an article titled “She was fit and healthy. Why did she get diabetes?” featuring the expertise of Fumihiko Urano, MD, PhD. Dr. Urano is a Professor of Medicine and of Pathology and Immunology with WashU Medicine’s Division of Endocrinology, Metabolism and Lipid Research, and Director of the Wolfram Syndrome International Registry and […]
When injured, cells have well-regulated responses to promote healing. These include a long-studied self-destruction process that cleans up dead and damaged cells as well as a more recently identified phenomenon that helps older cells revert to what appears to be a younger state to help grow back healthy tissue.
A new WashU Medicine study shows that acquired mutations in blood stem cells — whether arising from smoking, exposure to toxins or even normal aging — interact with mutations passed down by parents in important ways that influence a person’s lifetime risk of developing blood cancer. The knowledge could inform early detection and prevention.
WashU scientists are collaborating to unlock secrets of a millennia-old scourge. Efforts may lead to an increased understanding of and improved treatments for tuberculosis, which is once again on the rise.
Grant Challen, PhD, Professor, WashU Medicine Division of Oncology, teamed up with Luis F. Z. Batista, PhD, Associate Professor and Andrew L. Young, MD, PhD, Assistant Professor, WashU Medicine Division of Hematology, on a new research publication “Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity”, published this month in […]
A groundbreaking clinical trial utilizing technology developed previously by Jeffrey R. Millman, PhD has reported promising new findings in the treatment of type 1 diabetes (T1D). The study, conducted by Vertex Pharmaceuticals, evaluated a stem cell-derived islet (SC-islet) replacement therapy known as Zimislecel. In this Phase 1/2 trial, researchers implanted SC-islets into patients with T1D to replace the […]
Researchers at WashU Medicine’s Center for Cardiovascular Research have discovered that specialized immune cells from the spleen play a critical role in healing the heart after a heart attack. The study, led by Sumanth Prabhu, MD, Division Chief and director of the Prabhu Lab, identifies a unique population of macrophages—immune cells that clean up cellular debris—that travel […]
Siteman Cancer Center at Barnes-Jewish Hospital and WashU Medicine is pleased to announce funding for 12 new projects, including four clinical trials. Through this research, investigators aim to improve the understanding of tumor formation and growth, develop safer, more effective therapies, and explore new cancer screening strategies.
Tristan McIntosh, PhD & Alison Antes, PhD authored a paper in Frontiers in Research Metrics and Analytics titled “Evaluating and Supporting Leadership, Management, and Mentoring: A Framework for Catalyzing Responsible Research and Healthy Research Environments”.
The itching, redness and swelling of an allergic reaction are caused by mast cells — the vigilant first responders of the immune system that spring into action with histamine-filled granules in response to a perceived threat.
Anne Mobley Butler, PhD, MS, Associate Professor of Medicine in the Division of Infectious Diseases at WashU Medicine, was senior author of a study published in JAMA Network Open about the incidence of serious perinatal outcomes when treated for a urinary tract infection (UTI) during pregnancy . Co-authors include Michael Durkin, MD, MPH, Associate Professor of Medicine in […]
Researchers at the WashU Medicine Sah Lab in the Center for Cardiovascular Research and their collaborators have published findings that provide a proof of concept for a novel drug class to treat myocardial infarction and stroke. Rajan Sah, MD, PhD, a professor of medicine in the cardiovascular division, worked with multiple teams that collaborated to observe and describe a […]
Most cancer genome studies have focused on mutations in the tumor itself and how such gene variants allow a tumor to grow unchecked. A new study, led by researchers at Washington University School of Medicine in St. Louis, takes a deep dive into inherited cancer mutations measured in a healthy blood sample and reports how […]
As the opioid epidemic has worsened in the United States, prevalence of hepatitis C has also increased. Hepatitis C is a bloodborne virus that damages the liver. It is mainly spread through sharing needles or other injection equipment and can also be passed from a mother to baby during pregnancy or childbirth. It can be […]
William H. McCoy IV, MD, PhD, Assistant Professor in the Division of Dermatology at Washington University School of Medicine in St. Louis, recently published a manuscript in the Journal of Investigative Dermatology (JID).
Early this year, not long after President Donald Trump took office, his administration started terminating grants awarded by the National Institutes of Health (NIH), disrupting studies and unmooring biomedical and public health research communities.
Researchers at the WashU Medicine Sah Lab in the Center for Cardiovascular Research and their collaborators have published findings that provide a proof of concept for a novel drug class to treat myocardial infarction and stroke. Rajan Sah, MD, PhD, a professor of medicine in the cardiovascular division, worked with multiple teams that collaborated to observe and describe a […]
Bryce E. Montané, MD, Assistant Professor and Brian F. Gage, MD,MSc, Professor of Medicine, WashU Medicine Division of General Medicine and Geriatrics, led an interdisciplinary team to review trials of ablation of atrial fibrillation. They found that compared with medical therapy, catheter ablation reduced the relative risk for ischemic stroke by 37%, for death by […]
The first sickle cell disease patient in the St. Louis region has been successfully treated by WashU Medicine physicians at St. Louis Children’s Hospital with a gene therapy newly approved by the Food and Drug Administration.
A new study from Washington University School of Medicine in St. Louis identifies a possible way to slow or block progression of age-related macular degeneration, a leading cause of blindness in people over age 50. The WashU Medicine researchers and their international collaborators implicated problems with cholesterol metabolism in this type of vision loss, perhaps […]
The effects of a prospective sink environmental hygiene intervention on Pseudomonas aeruginosa and Stenotrophomonas maltophilia burden in hospital sinks Jennie Kwon, DO, MSCI, Associate Professor of Medicine at WashU Medicine’s Division of Infectious Diseases, co-published research in eBioMedicine about the burden of hygiene in hospital sinks. Co-principal investigators are; Gautam Dantas, PhD, Conan Professor of Laboratory and Genomic Medicine, and […]
Study Finds That Testosterone Gel Use in Women Recovering from Hip Fracture Does Not Improve Outcomes Compared to Supervised Exercise Alone Results from a recent multi-center, randomized, controlled trial demonstrate that testosterone gel does not improve physical function compared to exercise alone in older women recovering from a hip fracture. The STEP-HI study was published […]
A new type of immunotherapy that targets aggressive blood cancers shows promising results alongside manageable side effects, according to the results of an international phase 1/2 clinical trial led by researchers at Washington University School of Medicine in St. Louis.
In a clinical trial, researchers find moxidectin, a new medicine for river blindness, also works for lymphatic filariasis
In January, Marina Litvin, MD, an Associate Professor of Medicine at WashU Medicine’s Division of Endocrinology, Metabolism and Lipid Research, published an editorial titled “Metabolic Syndrome in the Post-ETI Era” in the Journal of Cystic Fibrosis.
An international phase 3 clinical trial led by Washington University School of Medicine in St. Louis and Dana-Farber Brigham Cancer Center shows that patients with certain locally advanced head and neck cancers benefited from the addition of the immunotherapy drug pembrolizumab (brand name Keytruda) to standard-of-care therapy.
On October 4, the American Academy of Sleep Medicine published an article titled “How weight loss medications are changing the sleep field,” featuring an interview with Raymond E. Bourey, MD, FAASM. Dr. Bourey has board certification, 25 years in sleep medicine, and is an Associate Professor of Medicine with WashU Medicine’s Division of Endocrinology, Metabolism and Lipid Research.
Faculty and other members of the Diwan Lab, including Professor of Medicine and Chief of Cardiology at the St. Louis VA Hospital Abhinav Diwan, MD, have published a new paper titled “Phosphorylation of CRYAB induces a condensatopathy to worsen post–myocardial infarction left ventricular remodeling”. The work was chosen for the cover feature of the latest issue of the Journal […]
Chronic kidney disease affects an estimated 37 million people in the U.S., and for many, there is no cure. But a new research project at Washington University in St. Louis seeks to change that by uncovering the mechanical basis of kidney cell injury.
Research developed through the collaborative efforts of WashU Medicine, the University of Abuja, Northwestern University, and The George Institute for Global Health have supported the launch of Nigeria’s Sodium Reduction Guidelines. William Bowen Endowed Professor of Medicine and Global Health Center Co-Director Mark Huffman, MD, MPH headed the WashU team for this NIH-funded project.
Researchers at WashU Medicine and the University of Texas Medical Branch have uncovered that drug resistance in Fasciola hepatica, a parasitic liver fluke that infects both humans and livestock, has emerged independently in different regions of the world. The findings, published in Nature Communications, are based on the analysis of more than 300 adult liver fluke samples […]
Nathaniel Hogrebe, PhD has always had an interest in science, and now, as a junior faculty member in the Millman Lab, he has steadily built a career as a leader in diabetes research, working closely with Dr. Millman to pioneer cutting-edge research in stem cell-derived islets (SC-islets).
Congratulations to Dr. Daphne Lew, Assistant Professor of Biostatistics, along with Dr. Alfred Kim, an Associate Professor in WashU Medicine’s Division of Rheumatology for being co-senior authors on an exciting publication in ACR Open Rheumatology on patient-reported social risk factor (SRF) screening among rheumatology outpatients.
Sina Jasim, MD, MPH; Allan Golding, MD; David Bimston, MD; Yang Chen, PhD; Ruochen Jiang, PhD; Yangyang Hao, PhD; Jing Huang, PhD; Joshua P. Klopper, MD; Richard T. Kloos, MD; and Taylor C. Brown, MD, MHS had their research article titled “Cytologic and Molecular Assessment of Isthmus Thyroid Nodules and Carcinomas,” published online ahead of print in the journal Thyroid.
Comparative Safety of Different Antibiotic Regimens for the Treatment of Outpatient Community-Acquired Pneumonia Among Otherwise Healthy Adults Anne Mobley Butler, PhD, Assistant Professor of Medicine, WashU Medicine – Division of Infectious Diseases, was recently shared in the IDSA daily news briefing. IDSA Daily News Briefing is written and distributed by the editors of Bulletin Healthcare, as […]
Health care-associated infections (HAIs) cause significant morbidity and mortality, but little is known about structural factors affecting race and rurality. Katelin B. Nickel, MPH, Sr. Programmer Analyst, WashU Medicine Division of Infectious Diseases along with Hannah Kinzer, MPH; Anne M. Butler, PhD, MS; Karen E. Joynt Maddox, MD, MPH; Victoria J. Fraser, MD, Adolphus Busch Professor of Medicine and Chair of the Department of Medicine; Jason P. Burnham, MD, […]
There’s a groundbreaking treatment being developed at WashU Medicine for women with an extremely aggressive form of breast cancer. A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors
From detection to treatment, mapping a new future for breast cancer. WashU Medicine physicians at Siteman Cancer Center are recognized nationally for their expertise in leading-edge breast cancer therapies. Nearly 50 specialists in surgery, breast reconstruction, medical oncology and radiation oncology, radiology and pathology are part of the Breast Cancer Program at Siteman, providing personalized treatment plans […]
Thomas Brett, PhD, Associate Professor of Medicine, Associate Professor of Cell Biology and Physiology, Associate Professor of Biochemistry and Molecular Biophysics, WashU Medicine Division of Pulmonary & Critical Care Medicine, Jen Alexander-Brett, MD, PhD, Assistant Professor of Medicine, WashU Medicine Division of Pulmonary and Critical Care Medicine, Daisy Leung, PhD, Professor, Departments of Medicine, Pathology […]
A recent study led by Beth Prusaczyk, PhD, MSW, Assistant Professor of Medicine in the Division of General Medicine & Geriatrics, looks at how barriers to healthcare social service utilization increases for rural area-based older adults who use drugs.
Each colored stripe in the image above represents a unique virus particle, with the width of each stripe reflecting the number of copies, in a hamster infected with SARS-CoV-2, the virus that causes COVID-19. Jacco Boon, PhD, a professor of medicine in the Division of Infectious Diseases, and colleagues have developed a tool to study […]
Brian Gage, MD, MSc, Professor of Medicine in the Division of General Medicine & Geriatrics, research on mycophenolic acid in lung transplant recipients has been published in the Journal of Heart and Lung Transplantation.
The first study to assess how weight-loss drugs affect the whole of human health has discovered an “eye-opening” impact on the body, researchers say.
Researchers are working with industry toward a clinical trial for blood cancer patients Two new studies led by researchers at Washington University School of Medicine in St. Louis have identified a possible way to block the progression of several forms of blood cancer using a drug already in clinical trials against breast cancer.
Off-the-shelf CAR-natural killer cells could expand accessibility, reduce cost of cell-based cancer therapies
Jeffrey P. Henderson, MD, PhD, FIDSA, Professor of Medicine and Molecular Microbiology, at WashU Division of Infectious Diseases, was recently published in ASM Journals with new insights into the development of a metabolome-based respiratory infection prognostic during COVID-19. Henderson highlights that the supportive environment at WashU Medicine played a crucial role in making this work possible, […]
The Washington University Kidney O’Brien Center for Chronic Kidney Disease Research, established in 2024, is excited to announce it is accepting applications for its 2nd immersive summer research program for undergraduate students interested in pursuing nephrology research.