Anuja Java, MD, Associate Professor of Medicine, Director, Kidney Transplant John Cochran VA Medical Center, Division of Nephrology, Washington University School of Medicine recently had two articles published in Science Direct. Thrombotic Microangiopathies and the Kidney Both articles delve into defining current understanding of the pathophysiological mechanisms underlying Thrombotic Microangiopathies (TMAs). TMA is a multisystem […]
Since 2020, the condition known as long COVID-19 has become a widespread disability affecting the health and quality of life of millions of people across the globe and costing economies billions of dollars in reduced productivity of employees and an overall drop in the work force.
Pretransplant desensitization of donor-specific anti-HLA antibodies with plasmapheresis and immunoglobulin produces equivalent outcomes to patients with no donor specific antibodies in haploidentical hematopoietic cell transplant Hunter Cassidy Cochran, MD, Hematology-Oncology Fellow, was recently published in Leukemia & Lymphoma. In many hematologic malignancies, hematopoietic cell transplant (HCT) is the only curative option. The likelihood of finding […]
DOLF investigators are beginning a follow-up study on the efficacy of a new combination treatment for lymphatic filariasis (LF) and onchocerciasis in the Akoupé district of Côte d’Ivoire. This study began July 4th and builds upon a large-scale community survey sponsored by Medicines Development for Global Health (MDGH).
Researchers in the Department of Medicine reveal new ways that human natural killer (NK) cells are rewired by signals through cytokine receptors to generate a memory-like program. In a report published in Science Immunology, co-first authors Jennifer Foltz, PhD, and Jennifer Tran build on prior work from senior author Todd Fehniger, MD, PhD, WashU Division […]
St. Louis-based center unites scientists, public health experts, nonprofits to fight virus
“Heavy and healthy” can be a rare or common condition. But either way it may signal that some excess weight is just fine.
Associate Professor of Medicine and Associate Director of the Wash U Hypertrophic Cardiomyopathy Center, Dr. Sharon Cresci is Vice-Chair on a new statement published this week in the journal Circulation on behalf of the American Heart Association.
Center will support new collaborations, infrastructure to accelerate precision medicine
“Hexamerization: explaining the original sin of IgG-mediated complement activation in acute lung injury” Hrishikesh S Kulkarni, MD, MSCI, Associate Professor of Medicine and Molecular Microbiology; Associate Program Director for Research, Division of Pulmonary and Critical Care Medicine, recently was published in the Journal of Clinical Investigation (JCI). The editorial in the Journal of Clinical Investigation […]
Congratulations to first-year fellow Susrutha Puthanmadhom Narayanan, MBBS, who presented her research at ASCO 2024 this past weekend entitled, “Transcriptomic Analysis of cAMP/PKA/CREB Signaling in Invasive Lobular Breast Cancer”.
Three dimensional images of human pancreatic islet cells provide an unprecedented view of the enigmatic primary cilia Jing Hughes, MD, Assistant Professor of Medicine, Division of Endocrinology, Metabolism & Lipid Research recent paper, “Scanning electron microscopy of human islet cilia” was published in Proceedings of the National Academy of Sciences (PNAS) and follow-up article, “Immuno-scanning […]
Artificial intelligence—the next wave of technology— is emerging in many ways in medical practices and health systems in the St. Louis area.
Genetically engineered B cells could produce super-antibodies to HIV
“Integration of Clinical Trial Development in Hematology-Oncology Fellowship Training” describes the Clinical Trial Development Program initiated at Washington University School of Medicine in 2002. This program was developed as a hands-on learning experience for Hematology-Oncology fellow in the design, implementation and publication of clinical trials and is led by Dr. Lee Ratner, Associate Program Director […]
Study also shows that patients hospitalized within 30 days after infection face 29% higher death risk in 3rd year compared with those not infected
The Hematology/Oncology Fellowship at Washington University School of Medicine is proud to announce that third-year fellow, Stefan Tarnawsky, M.D., Ph.D, has been selected by the American Society of Hematology (ASH) to participate in the 2024 Research Training Award for Fellows (RTAF).
Max Petersen, MD, PhD, Instructor in Medicine, Division of Endocrinology, Metabolism & Lipid Research, recently published a paper, Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity, in Cell Metabolism. The senior author of the study was Samuel Klein, MD, the William Danforth Professor of Medicine, and Chief of the Division of Nutritional Science & […]
Response to updated vaccine is shaped by earlier vaccines yet generates broadly neutralizing antibodies
(interview with Dr. Jeff Millman) Tell Us About Yourself My name is Jeff Millman, PhD, and I am a bioengineer within the Division of Endocrinology, Metabolism and Lipid Research in the Department of Medicine here at WashU. My bioengineering expertise uniquely positions me to pioneer research in a laboratory environment, with a steadfast commitment to […]
This past September, I had the opportunity to participate in an eye-opening event across the river from my hometown of Boston, MA. The event was a discussion of AI in medicine held on the campus of Harvard University. During the discussion, a senior faculty leader at Harvard Medical School commented to the effect that research […]
Leukemia & Lymphoma Society supports trials in cell-based immunotherapies, cancer vaccines
Recently, Fumihiko Urano, MD, PhD joined “It Happened to Me” podcast hosts Cathy Gildenhorn and Beth Glassman to discuss Wolfram syndrome and his ongoing research. Dr. Urano is the director of the Wolfram Syndrome International Registry & Clinical Study and the doctor of Cathy, who has a variant of the disease.
Congratulations to the research group headed by Jeffrey Miner, PhD, on their recent publication that landed the cover of Kidney International. The colorful cover photograph, illustrating paraffin immunofluorescence of different collagen IV chains, is a figure from their article “Quantitative assessment of glomerular basement membrane (GBM) collagen IV α chains in paraffin sections from patients with focal segmental glomerulosclerosis […]
Prostate cancer cellular immunotherapy Russell Pachynski, MD, Associate Professor of Medicine, Division of Oncology, Director of Genitourinary (GU) Oncology Research, Washington University School of Medicine in St. Louis, published a paper in Cancer Immunology Research (“High dimensional analyses reveal activation of lymphocyte subsets and reversal of immunoresistance by cytokine-enhanced cellular vaccine therapy in prostate cancer”) […]
Aditi Ramakrishnan, MD MSc, Assistant Professor in the Division of Infectious Diseases and Department of Medicine at the Washington University in St. Louis School of Medicine, had a first-author publication in Journal of Acquired Immune Deficiency Syndrome (JAIDS), a premier infectious diseases journal, describing the substance use treatment engagement among women with HIV in the […]
On March 5, Jeffrey Millman, PhD was featured on The Sugar Science’s Ask the Expert webinar series, hosted on YouTube. The episode was titled “Unraveling Cellular Complexity in Stem Cell-Derived Islet Identity through Single-Cell Sequencing.”
The Mbalaviele lab and collaborators found that inflammasomes play a critical role in bone loss in mice caused by the chemotherapeutic drug, doxorubicin. This finding may inspire the development of a tailored adjuvant therapy that preserves the quality of this tissue in patients treated with this class of drugs.
The document also strengthens advice regarding which medications should be started in all patients Thomas M. Maddox, MD, MSc, Professor of Medicine in the Cardiovascular Division at WashU Medicine, and colleagues recently published an Expert Consensus Decision Pathway (ECDP) for the many decisions required in the management and treatment of patients with heart failure with […]
“COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level,” clinical epidemiologist Ziyad Al-Aly said
Congratulations to the research team of the Mahjoub Laboratory, who are celebrating their multiple recent publications, one of which landed the cover of the journal JCI Insight.
Members of the Scheller Lab in collaboration with the Milbrandt and DiAntonio groups at WashU published a paper in JCI Insight in which they found that loss of Sarm1 could completely protect female mice against the development of bone loss and severe osteoblast suppression secondary to type 1 diabetes.
Cynthia Ma , MD, PhD, lead author and Professor of Medicine in the Division of Oncology along with her colleagues Kiran Vij, Jeremy Hoog, Mark Watson and Erika Crouch in the Department of Pathology investigated the role of neoadjuvant anastrazole, fulvestrant or the combination in a multi-institutional trial.
Study in Blood dissecting the role of NFκB signaling effectors in MPN disease biology Stephen T. Oh, MD, PhD, Co-Chief and Associate Professor of Medicine, Division of Hematology, Department of Medicine, Washington University School of Medicine in St. Louis, and has been published in Blood. The WashU group of researchers previously identified hyperactivation of NFκB […]
The study followed 113 patients at four different hospitals in Switzerland. A new study in Science is shining a light on the continuing impact of long COVID, with research revealing further and continuing health concerns for some of the 16 million sufferers in the U.S.
Researchers at Washington University School of Medicine in St. Louis have determined how Eastern equine encephalitis virus attaches to a receptor it uses to enter and infect cells. The whole virus is shown on the left and a magnified view of the viral structural proteins on the right. The findings laid the groundwork for a […]
Chronic kidney disease (CKD) is a highly under-recognized disease that affects almost 15% of the US population and carries significant morbidity and mortality. Although important scientific advances promise to accelerate CKD research, many are not accessible to the kidney research community due to limited expertise and/or the need for expensive equipment.
A study in Nature Cardiovascular Research by researchers at Washington University School of Medicine in St. Louis explores a new, noninvasive imaging technique that helps scientists visualize immune cells in the human heart.
On March 30, Cris Brown, BA and Fumihiko Urano, MD, PhD of Urano Lab, alongside colleagues from Belgique, Belgium and Italy, had their article titled “GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models,” published in Diabetologia.
A lifesaving cancer treatment may itself cause cancers, the Food and Drug Administration reported on Tuesday. The treatment, called CAR-T, was first approved in November 2017 for life-threatening blood cancers. But, the F.D.A. said, it had received 19 reports of new blood cancers in patients who received the treatment.
Radiotherapy may improve heart function by reducing inflammatory immune cells Cardiologists and radiation oncologists at Washington University School of Medicine in St. Louis pioneered the use of radiation therapy — a strategy typically used against cancer — to treat patients with a life-threatening abnormal heart rhythm called ventricular tachycardia.
Researchers at Washington University School of Medicine in St. Louis have found an innovative way to block infection by a variety of alphaviruses, a group of mosquito-borne viruses that can cause joint and brain infections in people. The study, led by Michael S. Diamond, MD, PhD, the Herbert S. Gasser Professor of Medicine, and Daved […]
In their newly-published article in Nature Communications, a multi-center group led by Ying Maggie Chen, MD, PhD, WashU Division of Nephrology, describes previously unknown mechanisms of action of mesencephalic astrocyte-derived neurotrophic factor (MANF) and its therapeutic function, with regards to kidney disease. MANF is a secreted endoplasmic reticulum (ER) protein that possesses cytoprotective properties.
Epigenetics of cancer critical in understanding tumor initiation, growth and spreading For decades, scientists have been sequencing the DNA of many cancer types, identifying errors in the genetic code to help understand the formation of tumors, how they grow and what leads to their spreading. But sometimes cancer is driven by subtle changes in the […]
Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine is pleased to announce funding for eight new projects, including research projects focused on prostate cancer, lymphoma, and breast cancer, as well as a team science project with a focus on myeloproliferative neoplasms, a blood malignancy that can develop into acute myeloid leukemia. Also included are two […]
Complete picture of genetic errors can advance precision medicine approaches to treatment A new test for two blood cancers — developed by a team at Washington University School of Medicine in St. Louis — is the first whole-genome sequencing test for cancer to be approved for reimbursement by the Centers for Medicare & Medicaid Services. […]
Understanding of molecular basis of cancer may lead to new therapies Scientists have completed a deep analysis of the proteins driving cancer across multiple tumor types, information that can’t be assessed by genome sequencing alone. Understanding how proteins operate in cancer cells raises the prospect of new therapies that block key proteins that drive cancer […]
Test results available in less than a minute Scientists at Washington University in St. Louis have developed a breath test that quickly identifies those who are infected with the virus that causes COVID-19. The device requires only one or two breaths and provides results in less than a minute.
Research collaboration details molecular knowledge, step toward personalized medicine Scientists at Washington University School of Medicine in St. Louis are among the leaders of a multi-institution research team that has built an atlas focused on the kidney’s myriad cells. The aim of the kidney tissue atlas is to further the understanding of kidney injury and disease.
Study could expand treatment options for patients with severe COVID-19 Two drugs commonly used to treat inflammatory diseases such as rheumatoid arthritis and psoriasis did not shorten recovery time for patients hospitalized with severe COVID-19 but did reduce the likelihood of death when compared with standard care alone, according to a national study led by […]