Radiation therapy may be potential heart failure treatment (Links to an external site)

Radiotherapy may improve heart function by reducing inflammatory immune cells Cardiologists and radiation oncologists at Washington University School of Medicine in St. Louis pioneered the use of radiation therapy — a strategy typically used against cancer — to treat patients with a life-threatening abnormal heart rhythm called ventricular tachycardia.

Researchers identify way to block alphavirus infection (Links to an external site)

Researchers at Washington University School of Medicine in St. Louis have found an innovative way to block infection by a variety of alphaviruses, a group of mosquito-borne viruses that can cause joint and brain infections in people. The study, led by Michael S. Diamond, MD, PhD, the Herbert S. Gasser Professor of Medicine, and Daved […]

Ying Maggie Chen Lab and Collaborators Uncover Biotherapeutic Properties of MANF Protein (Links to an external site)

Ying (Maggie) Chen, MD, PhD

In their newly-published article in Nature Communications, a multi-center group led by Ying Maggie Chen, MD, PhD, WashU Division of Nephrology, describes previously unknown mechanisms of action of mesencephalic astrocyte-derived neurotrophic factor (MANF) and its therapeutic function, with regards to kidney disease.  MANF is a secreted endoplasmic reticulum (ER) protein that possesses cytoprotective properties.

Epigenome’s role in cancer revealed in new study (Links to an external site)

Scientists at Washington University School of Medicine in St. Louis have analyzed the epigenomes of tumor cells across 11 cancer types and revealed important roles for this regulatory system of the genome in the way cancer forms, grows and spreads. (Image: Getty Images)

Epigenetics of cancer critical in understanding tumor initiation, growth and spreading For decades, scientists have been sequencing the DNA of many cancer types, identifying errors in the genetic code to help understand the formation of tumors, how they grow and what leads to their spreading. But sometimes cancer is driven by subtle changes in the […]

Siteman Investment Program awards $2 million in cancer research grants (Links to an external site)

Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine is pleased to announce funding for eight new projects, including research projects focused on prostate cancer, lymphoma, and breast cancer, as well as a team science project with a focus on myeloproliferative neoplasms, a blood malignancy that can develop into acute myeloid leukemia. Also included are two […]

Scientists reveal how proteins drive growth of multiple cancer types (Links to an external site)

Understanding of molecular basis of cancer may lead to new therapies Scientists have completed a deep analysis of the proteins driving cancer across multiple tumor types, information that can’t be assessed by genome sequencing alone. Understanding how proteins operate in cancer cells raises the prospect of new therapies that block key proteins that drive cancer […]

Kidney tissue atlas serves as blueprint for understanding kidney injury, disease (Links to an external site)

Research collaboration details molecular knowledge, step toward personalized medicine Scientists at Washington University School of Medicine in St. Louis are among the leaders of a multi-institution research team that has built an atlas focused on the kidney’s myriad cells. The aim of the kidney tissue atlas is to further the understanding of kidney injury and disease.

Anti-inflammatory drugs did not speed COVID-19 recovery but prevented deaths (Links to an external site)

Study could expand treatment options for patients with severe COVID-19 Two drugs commonly used to treat inflammatory diseases such as rheumatoid arthritis and psoriasis did not shorten recovery time for patients hospitalized with severe COVID-19 but did reduce the likelihood of death when compared with standard care alone, according to a national study led by […]

In battling obesity and prediabetes, combining exercise with weight loss is key (Links to an external site)

Insulin sensitivity improved twofold when exercise paired with 10% weight loss Researchers at Washington University School of Medicine in St. Louis have found that combining regular exercise with a 10% loss of body weight more than doubles sensitivity to insulin, compared with a 10% weight loss without exercise. Enhanced sensitivity to insulin has important health […]

Kidney donor updates for those with HCV and COVID-19

The association of donor hepatitis C virus infection with 3-year kidney transplant outcomes in the era of direct-acting antiviral medications Tarek Alhamad, MD, MS, MBA, Associate Professor of Medicine, Medical Director of Transplant Nephrology, Division of Nephrology, recently had two manuscripts published in JAMA Open and the American Journal of Transplantation regarding new findings of […]

Scanning electron microscopy of human islet cilia (Links to an external site)

Primary cilia are vital cell-surface sensory organelles, but their physical dimensions have eluded characterization due to difficulty in isolating and studying these enigmatic structures, especially in human tissues. In the present study, we use a multi-scale surface scanning approach to enable a 3D architectural study of human primary cilia, the first in pancreatic islets and […]

Dr. Fumihiko Urano featured in PBS Wolfram syndrome documentary  (Links to an external site)

Dr. Fumihiko Urano

In April, Fumihiko Urano, MD, PhD was featured in the documentary “Colorado Voices: Ellie White,” to raise awareness of the rare genetic disorder, Wolfram syndrome. The short documentary was published by Rocky Mountain PBS and tells the story of Colorado college student Ellie White, who lives with the disorder. Although the disorder is very rare […]

Red flags indicate risk for early-onset colorectal cancer (Links to an external site)

Researchers at Washington University School of Medicine in St. Louis have identified four important signs and symptoms that signal an elevated risk of early-onset colorectal cancer. These red flags may be key to earlier detection and diagnosis of early-onset colorectal cancer among younger adults. The number of young adults with colorectal cancer has nearly doubled […]

Kulkarni Lab investigates modulating host immune response in the lungs in severe pneumonia

Hrishikesh Kulkarni MD, MSCI, from the Division of Pulmonary and Critical Care Medicine recently had two manuscripts published in Science Immunology and a Phase 3 clinical Trial on complement inhibition in COVID-19 in the Lancet Respiratory Medicine. Lung epithelial cell–derived C3 protects against pneumonia-induced lung injury The complement cascade is made up of innate immune defense proteins that protect […]

Grant supports training physician-scientists in cancer research (Links to an external site)

Researchers at Washington University School of Medicine in St. Louis have received a grant from the National Institutes of Health (NIH) to support training and mentorship for early-career physician-scientists. This relatively new funding opportunity — called Stimulating Access to Research During Residency (StARR) — will provide support for early-career physicians pursuing careers in cancer research.

Noninvasive electromyometrial imaging (EMMI) of human uterine maturation during term labor

Noninvasive electromyometrial imaging of human uterine maturations during term labor

EMMI helps assess uterine contractions to aid in preventing preterm deliveries Dr. Phillip Cuculich, Cardiovascular Division at Washington University School of Medicine in St. Louis, shared new findings that were published in Nature Communication. The group of doctors led by Dr. Yong Wang, published the “first-in-woman” study blending the disciplines of cardiac electrophysiology and obstetrics. […]

Southern Society for Clinical Investigation (SSCI) – Important Upcoming Deadlines

SSCI Research Scholar Award Deadline – September 1Details and information on this $25,000 (plus 10% indirect costs) pilot funding award can be found at here. SRM 2023 Abstract Deadline – October 7Information on SRM 2023 and abstract submission will soon be available on our website. Abstract submission site will open August 1. SSCI Mentor of […]

Cornea appears to resist infection from novel coronavirus (Links to an external site)

New findings from researchers at Washington University School of Medicine in St. Louis suggest the eye’s cornea can resist infection from the novel coronavirus. Although the herpes simplex virus can infect the cornea and spread to other parts of the body in patients with compromised immune systems, and Zika virus has been found in tears […]

Washington University begins recruiting participants for phase 3 COVID-19 investigational vaccine clinical trial (Links to an external site)

Washington University School of Medicine in St. Louis is a testing site for the Janssen Pharmaceutical Companies of Johnson & Johnson’s phase 3 clinical research study, called the ENSEMBLE trial, to evaluate the safety and efficacy of Janssen’s investigational COVID-19 vaccine candidate, JNJ-78436735, also known as Ad26.COV2.S.