Radiotherapy may improve heart function by reducing inflammatory immune cells Cardiologists and radiation oncologists at Washington University School of Medicine in St. Louis pioneered the use of radiation therapy — a strategy typically used against cancer — to treat patients with a life-threatening abnormal heart rhythm called ventricular tachycardia.
Researchers at Washington University School of Medicine in St. Louis have found an innovative way to block infection by a variety of alphaviruses, a group of mosquito-borne viruses that can cause joint and brain infections in people. The study, led by Michael S. Diamond, MD, PhD, the Herbert S. Gasser Professor of Medicine, and Daved […]
In their newly-published article in Nature Communications, a multi-center group led by Ying Maggie Chen, MD, PhD, WashU Division of Nephrology, describes previously unknown mechanisms of action of mesencephalic astrocyte-derived neurotrophic factor (MANF) and its therapeutic function, with regards to kidney disease. MANF is a secreted endoplasmic reticulum (ER) protein that possesses cytoprotective properties.
Epigenetics of cancer critical in understanding tumor initiation, growth and spreading For decades, scientists have been sequencing the DNA of many cancer types, identifying errors in the genetic code to help understand the formation of tumors, how they grow and what leads to their spreading. But sometimes cancer is driven by subtle changes in the […]
Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine is pleased to announce funding for eight new projects, including research projects focused on prostate cancer, lymphoma, and breast cancer, as well as a team science project with a focus on myeloproliferative neoplasms, a blood malignancy that can develop into acute myeloid leukemia. Also included are two […]
Complete picture of genetic errors can advance precision medicine approaches to treatment A new test for two blood cancers — developed by a team at Washington University School of Medicine in St. Louis — is the first whole-genome sequencing test for cancer to be approved for reimbursement by the Centers for Medicare & Medicaid Services. […]
Understanding of molecular basis of cancer may lead to new therapies Scientists have completed a deep analysis of the proteins driving cancer across multiple tumor types, information that can’t be assessed by genome sequencing alone. Understanding how proteins operate in cancer cells raises the prospect of new therapies that block key proteins that drive cancer […]
Test results available in less than a minute Scientists at Washington University in St. Louis have developed a breath test that quickly identifies those who are infected with the virus that causes COVID-19. The device requires only one or two breaths and provides results in less than a minute.
Research collaboration details molecular knowledge, step toward personalized medicine Scientists at Washington University School of Medicine in St. Louis are among the leaders of a multi-institution research team that has built an atlas focused on the kidney’s myriad cells. The aim of the kidney tissue atlas is to further the understanding of kidney injury and disease.
Study could expand treatment options for patients with severe COVID-19 Two drugs commonly used to treat inflammatory diseases such as rheumatoid arthritis and psoriasis did not shorten recovery time for patients hospitalized with severe COVID-19 but did reduce the likelihood of death when compared with standard care alone, according to a national study led by […]
Insulin sensitivity improved twofold when exercise paired with 10% weight loss Researchers at Washington University School of Medicine in St. Louis have found that combining regular exercise with a 10% loss of body weight more than doubles sensitivity to insulin, compared with a 10% weight loss without exercise. Enhanced sensitivity to insulin has important health […]
Once a freak occurrence, fungi resistant to standard drugs now threaten millions of vulnerable Americans It took doctors a month to figure out a fungus had infected Glenda Brame’s bloodstream. The delay likely led to her death. The 56-year-old died in September, felled by a fungus that kills between 30% and 60% of people it […]
Studies in mice and in human immune cells link low prenatal vitamin D in mothers to insulin resistance in offspring Researchers at Washington University School of Medicine in St. Louis have identified a process in immune cells that links vitamin D deficiency during pregnancy to an increased risk of Type 2 diabetes in offspring. The […]
The association of donor hepatitis C virus infection with 3-year kidney transplant outcomes in the era of direct-acting antiviral medications Tarek Alhamad, MD, MS, MBA, Associate Professor of Medicine, Medical Director of Transplant Nephrology, Division of Nephrology, recently had two manuscripts published in JAMA Open and the American Journal of Transplantation regarding new findings of […]
Primary cilia are vital cell-surface sensory organelles, but their physical dimensions have eluded characterization due to difficulty in isolating and studying these enigmatic structures, especially in human tissues. In the present study, we use a multi-scale surface scanning approach to enable a 3D architectural study of human primary cilia, the first in pancreatic islets and […]
Diabetes researchers at Washington University School of Medicine in St. Louis have uncovered at least one reason insulin-secreting cells made from stem cells in the lab don’t work as well as natural cells. The discovery could help speed progress toward making insulin-secreting cells — called islet beta cells — more effective in the treatment of […]
In April, Fumihiko Urano, MD, PhD was featured in the documentary “Colorado Voices: Ellie White,” to raise awareness of the rare genetic disorder, Wolfram syndrome. The short documentary was published by Rocky Mountain PBS and tells the story of Colorado college student Ellie White, who lives with the disorder. Although the disorder is very rare […]
Researchers at Washington University School of Medicine in St. Louis have identified four important signs and symptoms that signal an elevated risk of early-onset colorectal cancer. These red flags may be key to earlier detection and diagnosis of early-onset colorectal cancer among younger adults. The number of young adults with colorectal cancer has nearly doubled […]
Hrishikesh Kulkarni MD, MSCI, from the Division of Pulmonary and Critical Care Medicine recently had two manuscripts published in Science Immunology and a Phase 3 clinical Trial on complement inhibition in COVID-19 in the Lancet Respiratory Medicine. Lung epithelial cell–derived C3 protects against pneumonia-induced lung injury The complement cascade is made up of innate immune defense proteins that protect […]
Researchers at Washington University School of Medicine in St. Louis have received a grant from the National Institutes of Health (NIH) to support training and mentorship for early-career physician-scientists. This relatively new funding opportunity — called Stimulating Access to Research During Residency (StARR) — will provide support for early-career physicians pursuing careers in cancer research.
EMMI helps assess uterine contractions to aid in preventing preterm deliveries Dr. Phillip Cuculich, Cardiovascular Division at Washington University School of Medicine in St. Louis, shared new findings that were published in Nature Communication. The group of doctors led by Dr. Yong Wang, published the “first-in-woman” study blending the disciplines of cardiac electrophysiology and obstetrics. […]
SSCI Research Scholar Award Deadline – September 1Details and information on this $25,000 (plus 10% indirect costs) pilot funding award can be found at here. SRM 2023 Abstract Deadline – October 7Information on SRM 2023 and abstract submission will soon be available on our website. Abstract submission site will open August 1. SSCI Mentor of […]
As part of ‘All of Us’ research program, School of Medicine will seek to enroll local participants
Sugary beverage consumption in adolescence, young adulthood associated with increased risk
Further studies underway to determine extent of clinical benefits
Study indicates timing of chemotherapy could improve treatment for deadly brain cancer
Independent of cholesterol, gene variants raise risk of heart disease, diabetes, high blood pressure
Virus-based therapy may unlock potential of immunotherapy for glioblastoma
Sequencing results returned in a few days; costs similar to conventional testing
Findings could help explain how asthma, COPD, severe COVID-19 are triggered
Researchers seek participants with diabetes that doesn’t fit type 1 or type 2 categories
Study reveals details of how coronavirus infects heart; models of tissue damage may help develop potential therapies
Research involving cytokines and how they’re packaged sheds light on inflammation in asthma, COPD, COVID-19
Washington University researchers part of team probing inflammation after heart attack
Glioblastoma study could lead to new treatments, including better immunotherapies
New grant to fund research into drugs that showed promise in small study of people with Crohn’s disease
Drugs that trigger alarm could lead to new HIV therapies
Findings could help improve treatment decisions
Medical school labs pivot to fight a common enemy
2 drugs targeting cancer cells’ energy source potentially could replace toxic chemo in osteosarcoma
Mice expressing increased levels of protein develop advanced liver disease
Measuring mitochondrial DNA could predict who will need ICU care, intubation
Newly identified pathway explains why antihistamine drugs often don’t work to control severe itch
Bacteria change surface of human intestine to benefit themselves
Bacteria change surface of human intestine to benefit themselves
Discovery of receptor, generation of decoy could help contain outbreaks of Venezuelan equine encephalitis virus
New findings from researchers at Washington University School of Medicine in St. Louis suggest the eye’s cornea can resist infection from the novel coronavirus. Although the herpes simplex virus can infect the cornea and spread to other parts of the body in patients with compromised immune systems, and Zika virus has been found in tears […]
Washington University School of Medicine in St. Louis is a testing site for the Janssen Pharmaceutical Companies of Johnson & Johnson’s phase 3 clinical research study, called the ENSEMBLE trial, to evaluate the safety and efficacy of Janssen’s investigational COVID-19 vaccine candidate, JNJ-78436735, also known as Ad26.COV2.S.
One of the most vexing aspects of the COVID-19 pandemic is the novel coronavirus’s ability to turn the body’s immune system against the body. After the virus has been cleared from the body, the immune system sometimes continues to hurtle an arsenal of immune proteins at the already vanquished virus, creating a dangerous inflammatory response […]