Lead author Clair Crewe, PhD, Assistant Professor of Medicine in WashU Medicine’s Division of Cell Biology and Physiology and Division of Endocrinology, Metabolism and Lipid Research, the Crewe Lab and collaborators from the Department of Pathology and Immunology and the Center for Human Nutrition are authors of a study published May 5, 2026, in Cell Metabolism.
Hookworms, intestinal parasites that infect hundreds of millions of people in under-resourced tropical regions around the globe, have evolved to survive inside the human gut for years, secreting molecules that enable co-existence with their hosts. Now, researchers at Washington University School of Medicine in St. Louis have harnessed that biological mechanism for potential human benefit, […]
Jeffrey R. Millman, PhD, Professor of Medicine in the Division of Endocrinology, Metabolism & Lipid Research at WashU Medicine, has received research funding from Breakthrough T1D to support his project titled “Overcoming Production Barriers to Stem Cell-Islet Therapies Through Scalable Technologies.” The two-year grant supports efforts to address key challenges in bringing manufactured islet cell therapies for type […]
SAN DIEGO, California – VANCOUVER, British Columbia, May 27, 2026 – Phoenix Molecular Designs (PhoenixMD), a clinical-stage precision oncology company developing first-in-class RSK kinase inhibitors, today announced the expansion of its lead asset PMD-026 into a second clinical indication with the initiation of Dauntless-3, an investigator-initiated Phase 1 trial in myelofibrosis at Washington University School […]
WashU Medicine infectious diseases researchers have developed a practical use of artificial intelligence to enhance patient safety, while potentially reducing costs and improving efficiency at hospitals. Abby Sung, MD, an assistant professor of medicine, and colleagues in the Division of Infectious Diseases, WashU McKelvey School of Engineering AI for Health Institute, and Barnes-Jewish Hospital (BJH) found that a large language model (LLM) can strengthen a semi-automated surveillance tool used by infection prevention.
Anne Carol Goldberg, MD, FACP, Professor of Medicine in the Division of Endocrinology, Metabolism & Lipid Research at WashU Medicine, is a co-author of a study published February 27, 2026, in Nature Medicine. The article, titled “Obicetrapib in patients with heterozygous familial hypercholesterolemia: the BROOKLYN randomized clinical trial,” explores a potential new option for people living […]
On March 1, Hani Soudah, MD, PhD, Associate Professor of Medicine in the Division of Endocrinology, Metabolism, & Lipid Research at WashU Medicine, along with collaborators, published a new systematic review and meta-analysis examining the broader physiological effects of semaglutide titled “A Systematic Review and Meta-Analysis of Semaglutide Effects on Adipose Tissue and Emerging Effects on Brain and Cognition.”
Irfan Lodhi, PhD, Professor of Medicine in the Division of Endocrinology, Metabolism & Lipid Research at WashU Medicine, and collaborators are authors of a study published January 8, 2026, in Nature Metabolism. The article, titled “A catecholamine-independent pathway controlling adaptive adipocyte lipolysis,” investigates how the body breaks down stable fat stores during conditions such as starvation, wasting and cachexia.
Jennifer Alexander‑Brett, MD, PhD, Associate Professor of Medicine, has been featured in a recent Nature Biotechnology article highlighting major advances in targeting interleukin‑33 (IL‑33) signaling in chronic obstructive pulmonary disease (COPD). The article, “Newcomer anti‑IL‑33 makes strides in COPD,” underscores the growing impact of IL‑33–focused therapeutics and the importance of foundational biological insight in translating discovery to patient […]
A personalized vaccine to treat glioblastoma, a fast-growing and incurable brain cancer that affects four in 100,000 people in the U.S., is safe and elicits robust and broad immune responses that appears to increase recurrence-free survival in a subset of patients after surgery, according to an early-stage clinical trial co-led by researchers at Washington University […]
A new multinational study finds that individuals with poor mental health consistently report lower-quality healthcare experiences across diverse health systems. Published May 5 in PLOS Medicine, the study was led by Margaret E. Kruk, MD, of Washington University School of Medicine in St. Louis, in collaboration with an international team of researchers.
Acute sinusitis leads to more antibiotic prescriptions for U.S. adults than any other condition, yet there has been no clear consensus on which antibiotic should be used for uncomplicated cases.
Janet B. McGill, MD, MA, FACE, FACP, Professor of Medicine in the Division of Endocrinology, Metabolism & Lipid Research at WashU Medicine, is the senior author of a study published March 5, 2026, in The New England Journal of Medicine.
A cell-based immunotherapy designed to treat rare and aggressive types of blood cancer has been granted Breakthrough Therapy designation by the U.S. Food and Drug Administration (FDA). Developed by researchers at Washington University School of Medicine in St. Louis, this innovative CAR-T cell therapy is licensed to Wugen, a WashU Medicine startup biotechnology company based […]
WashU Cardiovascular Division Global Health researchers have published a new article on disparity on heart failure care for Asian patients in the U.S. Mark Huffman, MD, MPH, William Bowen Endowed Professor of Medicine and Co-Director of the Global Health Center, and Anubha Agarwal, MD, MSc an associate professor of medicine and Co-Director of the Program in Global Cardiovascular Health […]
Following a rapid increase in popularity of GLP-1 drugs for diabetes and weight loss, such as semaglutide and tirzepatide, approximately one in eight U.S. adults now take these medications, which also provide cardiovascular benefits. However, when patients stop taking these drugs, they not only regain weight, but, according to a new study, they also incur […]
James Krings, MD, MSCI, Assistant Professor of Medicine, was recently published in Annals of Internal Medicine. The study, “A New Approach to Reliever Therapy in Asthma: Implications of the U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline”.
Researchers at WashU Medicine have identified a potent pathway that begins in the brain and leads to loss of all body fat without reducing food intake.
Researchers at Washington University School of Medicine in St. Louis show in a new study that GLP-1 medications may be effective at treating and preventing substance use disorders across all major addictive substances studied, suggesting these drugs target a common biological pathway underlying addiction.
Despite advances in the field of organ transplantation, long-term organ rejection that can become apparent a decade or more after a heart or lung transplant remains a common problem for patients. This chronic organ failure has long been attributed exclusively to the recipient’s immune system attacking the foreign organ over time.
White matter hyperintensity (WMH) burden is associated with cognitive decline, but its association with driving performance among older adults and the associations of modifiable risk factors remain unclear.
Sina Jasim, MD, MPH, associate professor of medicine in the Division of Endocrinology, Metabolism & Lipid Research at WashU Medicine, and Maria Papaleontiou, MD, associate professor of internal medicine in the Division of Metabolism, Endocrinology, and Diabetes at the University of Michigan, have published a narrative review in Thyroid®, the official journal of the American Thyroid Association.
Billions of dollars are invested each year in scientific research, yet too often the benefits stop at journal publications rather than reaching patients, communities or policymakers.
Max Petersen, MD, PhD, assistant professor of medicine in the Division of Endocrinology, Metabolism & Lipid Research at WashU Medicine, is the lead author of a new research article published in the Journal of Lipid Research, titled “Influence of obesity and insulin resistance with hepatic steatosis on the human plasma lipidome.”
In the U.S., one in eight women will get breast cancer in their lifetime, and about half of them will have mastectomies. Many of those women opt to have their breasts surgically reconstructed, most commonly with implants, but a relatively high percentage develop infections after implant surgery, requiring intravenous antibiotics and often removal of the […]
Since it was first detected in the U.S. in 2014, H5N1 avian influenza, commonly known as bird flu, has jumped from wild birds to farm animals and then to people, causing more than 70 human cases in the U.S. since 2022, including two fatalities. The virus continues to circulate among animals, giving it the opportunity […]
Scientists have designed an immunotherapy that reduces plaque in the arteries of mice, presenting a possible new treatment strategy against heart disease. The antibody-based therapy could complement traditional methods of managing coronary artery disease that focus on lowering cholesterol through diet or medications such as statins, according to the findings of a new study led […]
The human gut is home to trillions of beneficial microbes that play a crucial role in health. Disruptions in this delicate community of bacteria and viruses — called the gut microbiome — have been linked to obesity, asthma and cancer, among other illnesses.
An in-home mammalian meat reintroduction protocol was feasible and safe among patients with alpha-gal syndrome who had declining alpha-gal IgE titers and avoided red meat, according to study results.
A new study maps the immune cell landscape of bone marrow in patients with multiple myeloma, a rare cancer that develops in the plasma cells of the bone marrow and has no cure. This large immune cell atlas, which includes robust patient outcome data, provides unparalleled new insights into how the immune system interacts with […]
Startup companies built on Washington University in St. Louis discoveries attracted a record $1.7 billion in private-sector investment over the past year, accelerating the commercialization of WashU innovations into life-changing diagnostics, therapeutics and medical devices. Among those innovations are a blood test to diagnose Alzheimer’s disease; immunotherapies to treat aggressive blood cancers; and an AI-based […]
WashU Nephrology proudly recognizes Gonzalo Matzumura, MD, Assistant Professor of Medicine and Director of Acute Dialysis Services at Barnes-Jewish Hospital, for his role as co-author and investigator in the landmark LIBERATE‑D (Liberation from Acute Dialysis) trial, published in JAMA on November 7, 2025.
Researchers at Washington University School of Medicine in St. Louis have uncovered why some patients with a rare genetic disorder called primary ciliary dyskinesia have worse lung problems than others with the same disorder. The discovery, published in Science Translational Medicine, suggests that gene therapy to restore a missing protein complex could help treat the […]
Researchers at Washington University School of Medicine in St. Louis have identified central routes that two deadly viruses take to invade human cells and have designed decoy molecules that block the infections.
Sumanth Prabu, MD, Lewin Distinguished Professor of Cardiovascular Diseases and Chief of the WashU Cardiovascular Division, co-authored the 2025 scientific statement published by the American College of Cardiology on the role of inflammation in cardiovascular disease. The new statement reviews residual inflammatory risk, screening & management, and new anti-inflammatory strategies.
Julie M. Silverstein, MD, Professor of Medicine and Neurological Surgery, and Medical Director of the Pituitary Center in the Division of Endocrinology, Metabolism & Lipid Research at WashU Medicine, is co-author of a study published in The Journal of Clinical Endocrinology & Metabolism.
A new paper in JACC: Advances delves into the factors that may affect implementation of a polypill for heart failure with reduced ejection fraction (HFrEF)—assuming one proves safe and effective—and outlines strategies for an eventual rollout. This exercise “just reinforces the idea, in addition to previous data showing therapeutic inertia and reluctance to use other […]
Doxorubicin has been a mainstay in cancer treatment for more than 50 years. Sometimes called “red devil chemo,” it is potent and effective against many cancer types. But it comes with a major downside — increased risk of severe heart failure, even decades after successful cancer treatment.
Margo Girardi, MD, SFHM, and Gina LaRossa, MD, contributed to an abstract and article that were featured in the Society of Hospital Medicine’s Journal of Hospital Medicine. The article, titled “Putting SQuID on the menu: A subcutaneous insulin protocol for diabetic ketoacidosis,” demonstrates how using a subcutaneous insulin protocol on hospitalist units for low-to-moderate severity DKA […]
The World Health Organization (WHO) added cardiovascular polypills to its 2023 Model List of Essential Medicines, and research continues to show that these medications are effective at preventing atherosclerotic cardiovascular disease (ACD) among various other forms of cardiovascular disease. Yet experts say obstacles remain to the adoption of these medications in high-income developed nations.
Researchers at Washington University School of Medicine in St. Louis have identified a novel way brown fat — an energy-burning form of fat — can rev the body’s metabolic engine, consuming cellular fuel and producing heat in a way that improves metabolic health. The study, in mice, reveals new avenues to exploit brown fat to […]
A new preprint by Kameron Bradley of the Jeffrey Millman Lab, titled “Divergent Cell-Type Specific Hypoxia Responses in Human Stem Cell–Derived and Primary Islets,” sheds light on how different types of insulin-producing cells respond to oxygen deprivation, which is a common challenge in cell transplantation therapies for type 1 diabetes (T1D).
Dr. Jeffrey Millman, Professor of Medicine in the Division of Endocrinology, Metabolism and Lipid Research at Washington University School of Medicine, has co-authored a landmark review article on the heterogeneity of type 1 diabetes (T1D), published simultaneously on July 30 in three leading journals: Diabetologia, Diabetes, and Diabetes Care.
A new study published in the Journal of the American Medical Informatics Association (JAMIA) showcases how modern AI methods are advancing clinical and translational research in Neurofibromatosis type 1 (NF1). Conducted by Levi Kaster, BS, Ethan Hillis, MS, Inez Y. Oh, PhD, Elizabeth C. Cordell, MD, Randi E. Foraker, PhD, MA, Albert M. Lai, PhD, Stephanie M. Morris, […]
Hepatitis C, a bloodborne virus that damages the liver, can cause cirrhosis, liver cancer, liver failure and death if left untreated. Despite the availability of highly effective treatments, the prevalence of hepatitis C infection remains high, particularly among women of childbearing age, who account for more than one-fifth of chronic hepatitis C infections globally. Within […]
Malnutrition is a leading cause of death in children under age 5, and nearly 150 million children globally under this age have stunted growth from lack of nutrition. Although an inadequate diet is a major contributor, researchers at Washington University School of Medicine in St. Louis found over a decade ago that dysfunctional communities of gut […]
On August 4, The Washington Post published an article titled “She was fit and healthy. Why did she get diabetes?” featuring the expertise of Fumihiko Urano, MD, PhD. Dr. Urano is a Professor of Medicine and of Pathology and Immunology with WashU Medicine’s Division of Endocrinology, Metabolism and Lipid Research, and Director of the Wolfram Syndrome International Registry and […]
When injured, cells have well-regulated responses to promote healing. These include a long-studied self-destruction process that cleans up dead and damaged cells as well as a more recently identified phenomenon that helps older cells revert to what appears to be a younger state to help grow back healthy tissue.
A new WashU Medicine study shows that acquired mutations in blood stem cells — whether arising from smoking, exposure to toxins or even normal aging — interact with mutations passed down by parents in important ways that influence a person’s lifetime risk of developing blood cancer. The knowledge could inform early detection and prevention.
WashU scientists are collaborating to unlock secrets of a millennia-old scourge. Efforts may lead to an increased understanding of and improved treatments for tuberculosis, which is once again on the rise.