Kulkarni Editorial Published in Journal of Clinical Investigation

Hrishikesh S. Kulkarni, MD

“Hexamerization: explaining the original sin of IgG-mediated complement activation in acute lung injury” Hrishikesh S Kulkarni, MD, MSCI, Associate Professor of Medicine and Molecular Microbiology; Associate Program Director for Research, Division of Pulmonary and Critical Care Medicine, recently was published in the Journal of Clinical Investigation (JCI). The editorial in the Journal of Clinical Investigation […]

Hughes Lab publication highlighted in Science Snapshot

Researchers used scanning electron microscopy to image the cytoskeletal components of the human pancreatic primary cilia.

Three dimensional images of human pancreatic islet cells provide an unprecedented view of the enigmatic primary cilia Jing Hughes, MD, Assistant Professor of Medicine, Division of Endocrinology, Metabolism & Lipid Research recent paper, “Scanning electron microscopy of human islet cilia” was published in Proceedings of the National Academy of Sciences (PNAS) and follow-up article, “Immuno-scanning […]

Outcomes of Hematology/Oncology Clinical Trials Development Program Published by Co-Chief Fellow Christine Auberle (Links to an external site)

Christine Auberle, MD

“Integration of Clinical Trial Development in Hematology-Oncology Fellowship Training” describes the Clinical Trial Development Program initiated at Washington University School of Medicine in 2002. This program was developed as a hands-on learning experience for Hematology-Oncology fellow in the design, implementation and publication of clinical trials and is led by Dr. Lee Ratner, Associate Program Director […]

Petersen study of cardiometabolic health in obesity published in Cell Metabolism

Max Peterson, MD, PhD

Max Petersen, MD, PhD, Instructor in Medicine, Division of Endocrinology, Metabolism & Lipid Research, recently published a paper, Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity, in Cell Metabolism. The senior author of the study was Samuel Klein, MD, the William Danforth Professor of Medicine, and Chief of the Division of Nutritional Science & […]

Disrupting Type One Diabetes

Jeffrey Millman, PhD

(interview with Dr. Jeff Millman) Tell Us About Yourself My name is Jeff Millman, PhD, and I am a bioengineer within the Division of Endocrinology, Metabolism and Lipid Research in the Department of Medicine here at WashU. My bioengineering expertise uniquely positions me to pioneer research in a laboratory environment, with a steadfast commitment to […]

Dr. Jeffrey Miner’s Research Group Lands KI Journal Cover (Links to an external site)

Jeffrey H. Miner, PhD, FASN

Congratulations to the research group headed by Jeffrey Miner, PhD, on their recent publication that landed the cover of Kidney International.  The colorful cover photograph, illustrating paraffin immunofluorescence of different collagen IV chains, is a figure from their article “Quantitative assessment of glomerular basement membrane (GBM) collagen IV α chains in paraffin sections from patients with focal segmental glomerulosclerosis […]

High-Dimensional Analyses Reveal IL-15 Enhances Prostate Cancer Immunotherapy

Russell Pachynski, MD

Prostate cancer cellular immunotherapy Russell Pachynski, MD, Associate Professor of Medicine, Division of Oncology, Director of Genitourinary (GU) Oncology Research, Washington University School of Medicine in St. Louis, published a paper in Cancer Immunology Research (“High dimensional analyses reveal activation of lymphocyte subsets and reversal of immunoresistance by cytokine-enhanced cellular vaccine therapy in prostate cancer”) […]

HIV Clinicians Represent Critical Point of Access for Treatment of Substance Use

Aditi Ramakrishnan, MD

Aditi Ramakrishnan, MD MSc, Assistant Professor in the Division of Infectious Diseases and Department of Medicine at the Washington University in St. Louis School of Medicine, had a first-author publication in Journal of Acquired Immune Deficiency Syndrome (JAIDS), a premier infectious diseases journal, describing the substance use treatment engagement among women with HIV in the […]

Mbalaviele Lab Published in eLife (Links to an external site)

Mbalaviele Lab Published in eLife

The Mbalaviele lab and collaborators found that inflammasomes play a critical role in bone loss in mice caused by the chemotherapeutic drug, doxorubicin. This finding may inspire the development of a tailored adjuvant therapy that preserves the quality of this tissue in patients treated with this class of drugs.

ACC Updates HFrEF Decision Pathway, Reinforcing the Four Pillars of Therapy

Thomas M. Maddox, MD

The document also strengthens advice regarding which medications should be started in all patients Thomas M. Maddox, MD, MSc, Professor of Medicine in the Cardiovascular Division at WashU Medicine, and colleagues recently published an Expert Consensus Decision Pathway (ECDP) for the many decisions required in the management and treatment of patients with heart failure with […]

Scheller Lab and Colleagues Published in JCI Insight (Links to an external site)

Erica Scheller, DDS, PhD

Members of the Scheller Lab in collaboration with the Milbrandt and DiAntonio groups at WashU published a paper in JCI Insight in which they found that loss of Sarm1 could completely protect female mice against the development of bone loss and severe osteoblast suppression secondary to type 1 diabetes. 

In vivo ablation of NFκB cascade effectors alleviates disease burden in myeloproliferative neoplasms

Stephen T. Oh, MD, PhD

Study in Blood dissecting the role of NFκB signaling effectors in MPN disease biology Stephen T. Oh, MD, PhD, Co-Chief and Associate Professor of Medicine, Division of Hematology, Department of Medicine, Washington University School of Medicine in St. Louis, and has been published in Blood. The WashU group of researchers previously identified hyperactivation of NFκB […]

WashU Kidney O’Brien Center Takes CKD Research to the Next Level through Team Science (Links to an external site)

Washington University Kidney O’Brien Center for Chronic Kidney Disease Research

Chronic kidney disease (CKD) is a highly under-recognized disease that affects almost 15% of the US population and carries significant morbidity and mortality.  Although important scientific advances promise to accelerate CKD research, many are not accessible to the kidney research community due to limited expertise and/or the need for expensive equipment.

Radiation therapy may be potential heart failure treatment (Links to an external site)

Radiotherapy may improve heart function by reducing inflammatory immune cells Cardiologists and radiation oncologists at Washington University School of Medicine in St. Louis pioneered the use of radiation therapy — a strategy typically used against cancer — to treat patients with a life-threatening abnormal heart rhythm called ventricular tachycardia.

Researchers identify way to block alphavirus infection (Links to an external site)

Researchers at Washington University School of Medicine in St. Louis have found an innovative way to block infection by a variety of alphaviruses, a group of mosquito-borne viruses that can cause joint and brain infections in people. The study, led by Michael S. Diamond, MD, PhD, the Herbert S. Gasser Professor of Medicine, and Daved […]

Ying Maggie Chen Lab and Collaborators Uncover Biotherapeutic Properties of MANF Protein (Links to an external site)

Ying (Maggie) Chen, MD, PhD

In their newly-published article in Nature Communications, a multi-center group led by Ying Maggie Chen, MD, PhD, WashU Division of Nephrology, describes previously unknown mechanisms of action of mesencephalic astrocyte-derived neurotrophic factor (MANF) and its therapeutic function, with regards to kidney disease.  MANF is a secreted endoplasmic reticulum (ER) protein that possesses cytoprotective properties.

Epigenome’s role in cancer revealed in new study (Links to an external site)

Scientists at Washington University School of Medicine in St. Louis have analyzed the epigenomes of tumor cells across 11 cancer types and revealed important roles for this regulatory system of the genome in the way cancer forms, grows and spreads. (Image: Getty Images)

Epigenetics of cancer critical in understanding tumor initiation, growth and spreading For decades, scientists have been sequencing the DNA of many cancer types, identifying errors in the genetic code to help understand the formation of tumors, how they grow and what leads to their spreading. But sometimes cancer is driven by subtle changes in the […]

Siteman Investment Program awards $2 million in cancer research grants (Links to an external site)

Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine is pleased to announce funding for eight new projects, including research projects focused on prostate cancer, lymphoma, and breast cancer, as well as a team science project with a focus on myeloproliferative neoplasms, a blood malignancy that can develop into acute myeloid leukemia. Also included are two […]

Scientists reveal how proteins drive growth of multiple cancer types (Links to an external site)

Understanding of molecular basis of cancer may lead to new therapies Scientists have completed a deep analysis of the proteins driving cancer across multiple tumor types, information that can’t be assessed by genome sequencing alone. Understanding how proteins operate in cancer cells raises the prospect of new therapies that block key proteins that drive cancer […]

Kidney tissue atlas serves as blueprint for understanding kidney injury, disease (Links to an external site)

Research collaboration details molecular knowledge, step toward personalized medicine Scientists at Washington University School of Medicine in St. Louis are among the leaders of a multi-institution research team that has built an atlas focused on the kidney’s myriad cells. The aim of the kidney tissue atlas is to further the understanding of kidney injury and disease.

Anti-inflammatory drugs did not speed COVID-19 recovery but prevented deaths (Links to an external site)

Study could expand treatment options for patients with severe COVID-19 Two drugs commonly used to treat inflammatory diseases such as rheumatoid arthritis and psoriasis did not shorten recovery time for patients hospitalized with severe COVID-19 but did reduce the likelihood of death when compared with standard care alone, according to a national study led by […]

In battling obesity and prediabetes, combining exercise with weight loss is key (Links to an external site)

Insulin sensitivity improved twofold when exercise paired with 10% weight loss Researchers at Washington University School of Medicine in St. Louis have found that combining regular exercise with a 10% loss of body weight more than doubles sensitivity to insulin, compared with a 10% weight loss without exercise. Enhanced sensitivity to insulin has important health […]

Kidney donor updates for those with HCV and COVID-19

The association of donor hepatitis C virus infection with 3-year kidney transplant outcomes in the era of direct-acting antiviral medications Tarek Alhamad, MD, MS, MBA, Associate Professor of Medicine, Medical Director of Transplant Nephrology, Division of Nephrology, recently had two manuscripts published in JAMA Open and the American Journal of Transplantation regarding new findings of […]

Scanning electron microscopy of human islet cilia (Links to an external site)

Primary cilia are vital cell-surface sensory organelles, but their physical dimensions have eluded characterization due to difficulty in isolating and studying these enigmatic structures, especially in human tissues. In the present study, we use a multi-scale surface scanning approach to enable a 3D architectural study of human primary cilia, the first in pancreatic islets and […]

Dr. Fumihiko Urano featured in PBS Wolfram syndrome documentary  (Links to an external site)

Dr. Fumihiko Urano

In April, Fumihiko Urano, MD, PhD was featured in the documentary “Colorado Voices: Ellie White,” to raise awareness of the rare genetic disorder, Wolfram syndrome. The short documentary was published by Rocky Mountain PBS and tells the story of Colorado college student Ellie White, who lives with the disorder. Although the disorder is very rare […]

Red flags indicate risk for early-onset colorectal cancer (Links to an external site)

Researchers at Washington University School of Medicine in St. Louis have identified four important signs and symptoms that signal an elevated risk of early-onset colorectal cancer. These red flags may be key to earlier detection and diagnosis of early-onset colorectal cancer among younger adults. The number of young adults with colorectal cancer has nearly doubled […]

Kulkarni Lab investigates modulating host immune response in the lungs in severe pneumonia

Hrishikesh Kulkarni MD, MSCI, from the Division of Pulmonary and Critical Care Medicine recently had two manuscripts published in Science Immunology and a Phase 3 clinical Trial on complement inhibition in COVID-19 in the Lancet Respiratory Medicine. Lung epithelial cell–derived C3 protects against pneumonia-induced lung injury The complement cascade is made up of innate immune defense proteins that protect […]