Researchers at the WashU Medicine Sah Lab in the Center for Cardiovascular Research and their collaborators have published findings that provide a proof of concept for a novel drug class to treat myocardial infarction and stroke. Rajan Sah, MD, PhD, a professor of medicine in the cardiovascular division, worked with multiple teams that collaborated to observe and describe a […]
Bryce E. Montané, MD, Assistant Professor and Brian F. Gage, MD,MSc, Professor of Medicine, WashU Medicine Division of General Medicine and Geriatrics, led an interdisciplinary team to review trials of ablation of atrial fibrillation. They found that compared with medical therapy, catheter ablation reduced the relative risk for ischemic stroke by 37%, for death by […]
The first sickle cell disease patient in the St. Louis region has been successfully treated by WashU Medicine physicians at St. Louis Children’s Hospital with a gene therapy newly approved by the Food and Drug Administration.
A new study from Washington University School of Medicine in St. Louis identifies a possible way to slow or block progression of age-related macular degeneration, a leading cause of blindness in people over age 50. The WashU Medicine researchers and their international collaborators implicated problems with cholesterol metabolism in this type of vision loss, perhaps […]
The effects of a prospective sink environmental hygiene intervention on Pseudomonas aeruginosa and Stenotrophomonas maltophilia burden in hospital sinks Jennie Kwon, DO, MSCI, Associate Professor of Medicine at WashU Medicine’s Division of Infectious Diseases, co-published research in eBioMedicine about the burden of hygiene in hospital sinks. Co-principal investigators are; Gautam Dantas, PhD, Conan Professor of Laboratory and Genomic Medicine, and […]
Study Finds That Testosterone Gel Use in Women Recovering from Hip Fracture Does Not Improve Outcomes Compared to Supervised Exercise Alone Results from a recent multi-center, randomized, controlled trial demonstrate that testosterone gel does not improve physical function compared to exercise alone in older women recovering from a hip fracture. The STEP-HI study was published […]
A new type of immunotherapy that targets aggressive blood cancers shows promising results alongside manageable side effects, according to the results of an international phase 1/2 clinical trial led by researchers at Washington University School of Medicine in St. Louis.
In a clinical trial, researchers find moxidectin, a new medicine for river blindness, also works for lymphatic filariasis
In January, Marina Litvin, MD, an Associate Professor of Medicine at WashU Medicine’s Division of Endocrinology, Metabolism and Lipid Research, published an editorial titled “Metabolic Syndrome in the Post-ETI Era” in the Journal of Cystic Fibrosis.
An international phase 3 clinical trial led by Washington University School of Medicine in St. Louis and Dana-Farber Brigham Cancer Center shows that patients with certain locally advanced head and neck cancers benefited from the addition of the immunotherapy drug pembrolizumab (brand name Keytruda) to standard-of-care therapy.
On October 4, the American Academy of Sleep Medicine published an article titled “How weight loss medications are changing the sleep field,” featuring an interview with Raymond E. Bourey, MD, FAASM. Dr. Bourey has board certification, 25 years in sleep medicine, and is an Associate Professor of Medicine with WashU Medicine’s Division of Endocrinology, Metabolism and Lipid Research.
Faculty and other members of the Diwan Lab, including Professor of Medicine and Chief of Cardiology at the St. Louis VA Hospital Abhinav Diwan, MD, have published a new paper titled “Phosphorylation of CRYAB induces a condensatopathy to worsen post–myocardial infarction left ventricular remodeling”. The work was chosen for the cover feature of the latest issue of the Journal […]
Chronic kidney disease affects an estimated 37 million people in the U.S., and for many, there is no cure. But a new research project at Washington University in St. Louis seeks to change that by uncovering the mechanical basis of kidney cell injury.
Research developed through the collaborative efforts of WashU Medicine, the University of Abuja, Northwestern University, and The George Institute for Global Health have supported the launch of Nigeria’s Sodium Reduction Guidelines. William Bowen Endowed Professor of Medicine and Global Health Center Co-Director Mark Huffman, MD, MPH headed the WashU team for this NIH-funded project.
Researchers at WashU Medicine and the University of Texas Medical Branch have uncovered that drug resistance in Fasciola hepatica, a parasitic liver fluke that infects both humans and livestock, has emerged independently in different regions of the world. The findings, published in Nature Communications, are based on the analysis of more than 300 adult liver fluke samples […]
Nathaniel Hogrebe, PhD has always had an interest in science, and now, as a junior faculty member in the Millman Lab, he has steadily built a career as a leader in diabetes research, working closely with Dr. Millman to pioneer cutting-edge research in stem cell-derived islets (SC-islets).
Congratulations to Dr. Daphne Lew, Assistant Professor of Biostatistics, along with Dr. Alfred Kim, an Associate Professor in WashU Medicine’s Division of Rheumatology for being co-senior authors on an exciting publication in ACR Open Rheumatology on patient-reported social risk factor (SRF) screening among rheumatology outpatients.
Sina Jasim, MD, MPH; Allan Golding, MD; David Bimston, MD; Yang Chen, PhD; Ruochen Jiang, PhD; Yangyang Hao, PhD; Jing Huang, PhD; Joshua P. Klopper, MD; Richard T. Kloos, MD; and Taylor C. Brown, MD, MHS had their research article titled “Cytologic and Molecular Assessment of Isthmus Thyroid Nodules and Carcinomas,” published online ahead of print in the journal Thyroid.
Comparative Safety of Different Antibiotic Regimens for the Treatment of Outpatient Community-Acquired Pneumonia Among Otherwise Healthy Adults Anne Mobley Butler, PhD, Assistant Professor of Medicine, WashU Medicine – Division of Infectious Diseases, was recently shared in the IDSA daily news briefing. IDSA Daily News Briefing is written and distributed by the editors of Bulletin Healthcare, as […]
Health care-associated infections (HAIs) cause significant morbidity and mortality, but little is known about structural factors affecting race and rurality. Katelin B. Nickel, MPH, Sr. Programmer Analyst, WashU Medicine Division of Infectious Diseases along with Hannah Kinzer, MPH; Anne M. Butler, PhD, MS; Karen E. Joynt Maddox, MD, MPH; Victoria J. Fraser, MD, Adolphus Busch Professor of Medicine and Chair of the Department of Medicine; Jason P. Burnham, MD, […]
There’s a groundbreaking treatment being developed at WashU Medicine for women with an extremely aggressive form of breast cancer. A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors
From detection to treatment, mapping a new future for breast cancer. WashU Medicine physicians at Siteman Cancer Center are recognized nationally for their expertise in leading-edge breast cancer therapies. Nearly 50 specialists in surgery, breast reconstruction, medical oncology and radiation oncology, radiology and pathology are part of the Breast Cancer Program at Siteman, providing personalized treatment plans […]
Thomas Brett, PhD, Associate Professor of Medicine, Associate Professor of Cell Biology and Physiology, Associate Professor of Biochemistry and Molecular Biophysics, WashU Medicine Division of Pulmonary & Critical Care Medicine, Jen Alexander-Brett, MD, PhD, Assistant Professor of Medicine, WashU Medicine Division of Pulmonary and Critical Care Medicine, Daisy Leung, PhD, Professor, Departments of Medicine, Pathology […]
A recent study led by Beth Prusaczyk, PhD, MSW, Assistant Professor of Medicine in the Division of General Medicine & Geriatrics, looks at how barriers to healthcare social service utilization increases for rural area-based older adults who use drugs.
Each colored stripe in the image above represents a unique virus particle, with the width of each stripe reflecting the number of copies, in a hamster infected with SARS-CoV-2, the virus that causes COVID-19. Jacco Boon, PhD, a professor of medicine in the Division of Infectious Diseases, and colleagues have developed a tool to study […]
Brian Gage, MD, MSc, Professor of Medicine in the Division of General Medicine & Geriatrics, research on mycophenolic acid in lung transplant recipients has been published in the Journal of Heart and Lung Transplantation.
The first study to assess how weight-loss drugs affect the whole of human health has discovered an “eye-opening” impact on the body, researchers say.
Researchers are working with industry toward a clinical trial for blood cancer patients Two new studies led by researchers at Washington University School of Medicine in St. Louis have identified a possible way to block the progression of several forms of blood cancer using a drug already in clinical trials against breast cancer.
Off-the-shelf CAR-natural killer cells could expand accessibility, reduce cost of cell-based cancer therapies
Jeffrey P. Henderson, MD, PhD, FIDSA, Professor of Medicine and Molecular Microbiology, at WashU Division of Infectious Diseases, was recently published in ASM Journals with new insights into the development of a metabolome-based respiratory infection prognostic during COVID-19. Henderson highlights that the supportive environment at WashU Medicine played a crucial role in making this work possible, […]
The Washington University Kidney O’Brien Center for Chronic Kidney Disease Research, established in 2024, is excited to announce it is accepting applications for its 2nd immersive summer research program for undergraduate students interested in pursuing nephrology research.
In March, Samantha Adamson, MD, PhD; Sangeeta Adak, PhD; Max C. Petersen, MD, PhD; Dustin Higgins, DO; Larry D. Spears, PhD; Rong Mei Zhang, MD; Andrea Cedeno, MD; Alexis McKee, MD, CDCES; Aswathi Kumar, MD; Sudhir M. Singh, MD; Fong-Fu Hsu, PhD; Janet B. McGill, MD, MA, FACP; and Clay F. Semenkovich, MD had their article titled “Decreased sarcoplasmic reticulum phospholipids in human skeletal muscle are associated with metabolic […]
The brightest minds solving brain cancer’s toughest challenges. Brain tumors are among the most challenging cancers to effectively treat. Depending on the tumor’s location, surgery can interfere with cognitive function, movement or language, and surgery often is not the solution because the tumor cells are invasive and intertwined with normal brain cells. Additionally, the brain’s […]
For the first time, annual research funding to Washington University in St. Louis has surpassed $1 billion. External funding supports WashU investigators tackling big challenges from Alzheimer’s disease to air pollution to childhood depression. Research funding also ripples across the economy, sparking job growth, new construction and local spending, said Chancellor Andrew D. Martin.
Clinical trial indicates safety, fewer cases of life-threatening graft-versus-host disease than expected Adding a new drug to standard care for stem cell transplant recipients may reduce a life-threatening side effect, according to an early-stage clinical trial conducted at Washington University School of Medicine in St. Louis. The trial showed that patients being treated for various […]
A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors. Conducted at Washington University School of Medicine in St. Louis with a therapy designed by Washington University researchers, the trial is the first to report results for this type of vaccine — known […]
A polypill is suggested containing all 4 classes of guideline-directed medical therapy for heart failure Justin Chen, MD, First Year Cardiology Fellow, First Author along with Anubha Agarwal, MD, MSc, Assistant Professor of Medicine, Co-Director, Program in Global Cardiovascular Health, WashU Medicine Cardiovascular Division, Senior Author, have published in Circulation: Cardiovascular Quality and Outcomes. The […]
A new analysis led by researchers at Washington University School of Medicine in St. Louis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells — and the cells of a tumor’s surrounding environment — are organized, in 3D, and how that organization changes […]
The Center for Dissemination and Implementation announces the launch of a new Midwest Developmental Center for AIDS Research (D-CFAR) in Missouri, which brings together researchers from across the translational spectrum to address the HIV epidemic. This D-CFAR is part of a national network of 20 NIH-funded centers, and it is the first of its kind […]
A new research network initiative is being launched by Sunny Lin, PhD, MS, in the Division of General Medicine & Geriatrics – Research Unit.
W. Kimryn Rathmell, MD, PhD, the director of the National Cancer Institute (NCI) of the National Institutes of Health (NIH), delivered the 19th annual Stanley J. Korsmeyer Memorial Lectureship at Washington University School of Medicine in St. Louis on Thursday, Oct. 17. Korsmeyer was a former WashU Medicine medical oncologist and researcher whose groundbreaking discoveries opened up […]
Gewin’s team aims to find ways to promote kidney repair and prevent the progression of fibrosis. Dr. Leslie Gewin, a nephrologist and researcher, has been steadily expanding her research into kidney disease since moving from Vanderbilt to WashU Medicine three years ago. Leveraging the university’s extensive resources and collaborative environment, Gewin’s work focuses on the […]
A new study from Washington University School of Medicine in St. Louis suggests that a type of immunotherapy — similar to that approved by the Food and Drug Administration (FDA) to treat inflammatory conditions such as arthritis — also may be an effective treatment strategy for heart failure.
Host De-ubiquitinase USP8 promotes Mycobacterium tuberculosis infection Pallavi Chandra, PhD, an Instructor of Medicine in the Philips laboratory at WashU Medicine Division of Infectious Diseases, along with Jennifer A. Philips, MD, PhD, Theodore and Bertha Bryan Professor, Departments of Medicine and Molecular Microbiology; Co-director, Infectious Diseases Division, recently co-authored a Autophagy publication, on Mycobacterium tuberculosis (Mtb) and USP8. […]
Gentle nasal spray vaccines against COVID, the flu and RSV are coming. They may work better than shots in the arm
Congratulations to Carmen Halabi, MD, PhD, Associate Professor, Pediatrics, Nephrology, and collaborator Jeffrey Miner, PhD, FASN, Eduardo and Judith Slatopolsky Professor of Medicine in Nephrology, who were awarded an Alport Syndrome Foundation (ASF) grant to fund research into the presence of aortic aneurysms in Alport mice.
Researchers at Washington University School of Medicine in St. Louis have developed a new genomic-based approach that could aid global efforts to eliminate lymphatic filariasis, a parasitic roundworm infection spread by mosquitoes.
Type 1 diabetes — one of the most common chronic diseases in children — destroys insulin-producing cells in the pancreas, requiring lifelong daily management. The autoimmune disease affects up to 10% of people with diabetes worldwide.
A component of beet juice — inorganic nitrate — improves muscle power and exercise capacity in athletes and in patients with heart failure, according to earlier research by a team at Washington University School of Medicine in St. Louis.
Mycobacterium tuberculosis virulence lipid PDIM inhibits autophagy in mice Jennifer A. Philips, MD, PhD, Theodore and Bertha Bryan Professor, Departments of Medicine and Molecular Microbiology; Co-director, Infectious Diseases Division, recently co-authored a Nature Microbiology publication, with Ekansh Mittal, PhD, Instructor of Medicine, WashU Division of Infectious Diseases, on Mycobacterium tuberculosis (Mtb). Dr. Philips is the principal investigator […]