Category: Research and Publications

Study in hamsters indicates vaccines targeting nose, mouth may be key to controlling spread of respiratory infections

Marlie Maestas, a fifth-year graduate student in the Millman Lab, recently published her first first-authorship in Nature Communications. The study, titled Identification of unique cell type responses in pancreatic islets to stress, detailed the responses of different pancreatic islet cell types to endoplasmic reticulum and inflammatory stress.

Anuja Java, MD, Associate Professor of Medicine, Director, Kidney Transplant John Cochran VA Medical Center, Division of Nephrology, Washington University School of Medicine recently had two articles published in Science Direct. Thrombotic Microangiopathies and the Kidney Both articles delve into defining current understanding of the pathophysiological mechanisms underlying Thrombotic Microangiopathies (TMAs). TMA is a multisystem […]

Pretransplant desensitization of donor-specific anti-HLA antibodies with plasmapheresis and immunoglobulin produces equivalent outcomes to patients with no donor specific antibodies in haploidentical hematopoietic cell transplant Hunter Cassidy Cochran, MD, Hematology-Oncology Fellow, was recently published in Leukemia & Lymphoma. In many hematologic malignancies, hematopoietic cell transplant (HCT) is the only curative option. The likelihood of finding […]

DOLF investigators are beginning a follow-up study on the efficacy of a new combination treatment for lymphatic filariasis (LF) and onchocerciasis in the Akoupé district of Côte d’Ivoire. This study began July 4th and builds upon a large-scale community survey sponsored by Medicines Development for Global Health (MDGH).

Researchers in the Department of Medicine reveal new ways that human natural killer (NK) cells are rewired by signals through cytokine receptors to generate a memory-like program.  In a report published in Science Immunology, co-first authors Jennifer Foltz, PhD, and Jennifer Tran build on prior work from senior author Todd Fehniger, MD, PhD, WashU Division […]

St. Louis-based center unites scientists, public health experts, nonprofits to fight virus

“Heavy and healthy” can be a rare or common condition. But either way it may signal that some excess weight is just fine.

Associate Professor of Medicine and Associate Director of the Wash U Hypertrophic Cardiomyopathy Center, Dr. Sharon Cresci is Vice-Chair on a new statement published this week in the journal Circulation on behalf of the American Heart Association.

Center will support new collaborations, infrastructure to accelerate precision medicine

“Hexamerization: explaining the original sin of IgG-mediated complement activation in acute lung injury” Hrishikesh S Kulkarni, MD, MSCI, Associate Professor of Medicine and Molecular Microbiology; Associate Program Director for Research, Division of Pulmonary and Critical Care Medicine, recently was published in the Journal of Clinical Investigation (JCI). The editorial in the Journal of Clinical Investigation […]

Congratulations to first-year fellow Susrutha Puthanmadhom Narayanan, MBBS, who presented her research at ASCO 2024 this past weekend entitled, “Transcriptomic Analysis of cAMP/PKA/CREB Signaling in Invasive Lobular Breast Cancer”. 

Three dimensional images of human pancreatic islet cells provide an unprecedented view of the enigmatic primary cilia Jing Hughes, MD, Assistant Professor of Medicine, Division of Endocrinology, Metabolism & Lipid Research recent paper, “Scanning electron microscopy of human islet cilia” was published in Proceedings of the National Academy of Sciences (PNAS) and follow-up article, “Immuno-scanning […]

Artificial intelligence—the next wave of technology— is emerging in many ways in medical practices and health systems in the St. Louis area.

Genetically engineered B cells could produce super-antibodies to HIV

“Integration of Clinical Trial Development in Hematology-Oncology Fellowship Training” describes the Clinical Trial Development Program initiated at Washington University School of Medicine in 2002. This program was developed as a hands-on learning experience for Hematology-Oncology fellow in the design, implementation and publication of clinical trials and is led by Dr. Lee Ratner, Associate Program Director […]

Study also shows that patients hospitalized within 30 days after infection face 29% higher death risk in 3rd year compared with those not infected

(interview with Dr. Jeff Millman) Tell Us About Yourself My name is Jeff Millman, PhD, and I am a bioengineer within the Division of Endocrinology, Metabolism and Lipid Research in the Department of Medicine here at WashU. My bioengineering expertise uniquely positions me to pioneer research in a laboratory environment, with a steadfast commitment to […]

Congratulations to the research group headed by Jeffrey Miner, PhD, on their recent publication that landed the cover of Kidney International.  The colorful cover photograph, illustrating paraffin immunofluorescence of different collagen IV chains, is a figure from their article “Quantitative assessment of glomerular basement membrane (GBM) collagen IV α chains in paraffin sections from patients with focal segmental glomerulosclerosis […]

Prostate cancer cellular immunotherapy Russell Pachynski, MD, Associate Professor of Medicine, Division of Oncology, Director of Genitourinary (GU) Oncology Research, Washington University School of Medicine in St. Louis, published a paper in Cancer Immunology Research (“High dimensional analyses reveal activation of lymphocyte subsets and reversal of immunoresistance by cytokine-enhanced cellular vaccine therapy in prostate cancer”) […]

Aditi Ramakrishnan, MD MSc, Assistant Professor in the Division of Infectious Diseases and Department of Medicine at the Washington University in St. Louis School of Medicine, had a first-author publication in Journal of Acquired Immune Deficiency Syndrome (JAIDS), a premier infectious diseases journal, describing the substance use treatment engagement among women with HIV in the […]

The document also strengthens advice regarding which medications should be started in all patients Thomas M. Maddox, MD, MSc, Professor of Medicine in the Cardiovascular Division at WashU Medicine, and colleagues recently published an Expert Consensus Decision Pathway (ECDP) for the many decisions required in the management and treatment of patients with heart failure with […]

“COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level,” clinical epidemiologist Ziyad Al-Aly said

Congratulations to the research team of the Mahjoub Laboratory, who are celebrating their multiple recent publications, one of which landed the cover of the journal JCI Insight.