Category: Research and Publications

High-Dimensional Analyses Reveal IL-15 Enhances Prostate Cancer Immunotherapy

Russell Pachynski, MD

Prostate cancer cellular immunotherapy Russell Pachynski, MD, Associate Professor of Medicine, Division of Oncology, Director of Genitourinary (GU) Oncology Research, Washington University School of Medicine in St. Louis, published a paper in Cancer Immunology Research (“High dimensional analyses reveal activation of lymphocyte subsets and reversal of immunoresistance by cytokine-enhanced cellular vaccine therapy in prostate cancer”) […]

HIV Clinicians Represent Critical Point of Access for Treatment of Substance Use

Aditi Ramakrishnan, MD

Aditi Ramakrishnan, MD MSc, Assistant Professor in the Division of Infectious Diseases and Department of Medicine at the Washington University in St. Louis School of Medicine, had a first-author publication in Journal of Acquired Immune Deficiency Syndrome (JAIDS), a premier infectious diseases journal, describing the substance use treatment engagement among women with HIV in the […]

New research shows urgency to act on Nigeria’s trans fat elimination policy

istock-image

Significantly reducing trans fat levels in the Nigerian food supply could prevent approximately 10,000 heart disease deaths and save 90 million USD (12 billion Naira, ₦) in healthcare costs over a decade. New findings by The George Institute for Global Health on the health and economic benefits of enacting the country’s trans fat elimination policy […]

Thakker Coauthors Research Letter in JACC (Links to an external site)

Prashanth Thakker, MD

Dr. Prashanth Thakker, Assistant Professor of Medicine and Associate Director of Program Development in the Cardiovascular Fellowship program was coauthor of a research letter published in the Journal of the American College of Cardiology titled “A Leadership Program to Support Career Development of Cardiovascular Chief Fellows”.

Artificial Intelligence for Cardiovascular Care

Thomas M. Maddox, MD

Thomas M. Maddox, MD, MSc, Professor of Medicine, Cardiovascular Division at WashU Medicine, and colleagues recently published two articles outlining the current opportunities for AI to impact cardiovascular care. These articles highlight how AI is poised to affect almost every aspect of cardiovascular care. ” says Maddox. “Our group hopes that this work helps prepare […]

ACC Updates HFrEF Decision Pathway, Reinforcing the Four Pillars of Therapy

Thomas M. Maddox, MD

The document also strengthens advice regarding which medications should be started in all patients Thomas M. Maddox, MD, MSc, Professor of Medicine in the Cardiovascular Division at WashU Medicine, and colleagues recently published an Expert Consensus Decision Pathway (ECDP) for the many decisions required in the management and treatment of patients with heart failure with […]

McNerney and Jasim discuss the long-term endocrine effects of cancer treatment  (Links to an external site)

Kyle P. McNerney, MD of the Department of Pediatrics at Washington University School of Medicine and Sina Jasim, MD of the Division of Endocrinology, Metabolism and Lipid Research

On October 10, 2023, Kyle P. McNerney, MD of the Department of Pediatrics at Washington University School of Medicine and Sina Jasim, MD of the Division of Endocrinology, Metabolism and Lipid Research, had their book chapter titled “Long-Term Effects of Cancer Treatment” published in Familial Endocrine Cancer Syndromes: Navigating the Transition of Care for Pediatric and Adolescent Patients.  

Some sarcoma patients improve with T cell immunotherapy (Links to an external site)

According to a study led by Washington University School of Medicine in St. Louis, a new T cell immunotherapy — in which the patients’ own T cells are genetically modified to attack and kill cancer cells — is effective in treating some patients with two types of sarcoma, rare cancers of the body’s soft tissues. Shown is a cross section of a synovial sarcoma tumor.

Strategy effective against some rare, aggressive sarcomas with no other treatment options A clinical trial led by researchers at Washington University School of Medicine in St. Louis has shown that a T cell immunotherapy — in which the patients’ own T cells are genetically modified to attack and kill cancer cells — is effective in […]

Powers Carson and Arora discuss negative correlations between BMI and glycated albumin  (Links to an external site)

Jennifer Powers Carson, PhD

In October of 2023, Jennifer Powers Carson, PhD and colleague, Jyoti Arora, MS of the Washington University School of Medicine, Center for Biostatistics and Data Science, had their work published by Clinical Biochemistry. The article was titled, “Glycated serum proteins and albumin but not glycated albumin show negative correlation with BMI in an overweight/obese, diabetic population from the United States.” 

AI may predict spread of lung cancer to brain (Links to an external site)

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Method may inform personalized cancer treatments Physicians treating patients with early-stage lung cancer face a conundrum: choosing potentially helpful yet toxic therapies such as chemotherapy, radiation or immunotherapy to knock out the cancer and lessen the risk of it spreading to the brain, or waiting to see if lung surgery alone proves sufficient. When up […]

WashU Medicine rises to No. 2 in nation in NIH research funding (Links to an external site)

Washington University School of Medicine in St. Louis received in 2023 the second highest amount of funding from the National Institutes of Health (NIH) of all medical schools nationwide. This ranking reflects the school’s commitment to cutting-edge research and positions it as a key player in shaping the future of medicine. (Photo: Matt Miller/School of Medicine)

Ranking reflects success as thriving hub of scientific excellence, medical innovation In the realm of biomedical research, securing funding is a testament to an institution’s record of scientific accomplishments and potential for further advances to improve human health. In 2023, Washington University School of Medicine in St. Louis received the second-highest amount of funding from […]

Dr. David DeNardo Explores How the Tumor Microenvironment Affects Immune Responses to Cancer (Links to an external site)

David DeNardo, P.D

David DeNardo, Ph.D., is a Professor of Medicine and Co-Director of the Tumor Immunology Program at the Washington University St. Louis, School of Medicine.  His research team is working to understand why responses to cancer immunotherapy vary among patients. In studying and uncovering mechanisms of cancer immunology, Dr. DeNardo aims to identify strategies that can […]

Brain tumors: Fighting with targeted tools (Links to an external site)

Neurosurgeon Albert Kim, MD, PhD (center), and chief resident Adam Bevan, MD, PhD, perform a right parietal craniotomy to remove a brain tumor.

Whether malignant or benign, a brain tumor is life-altering. Malignant tumors can spread and become deadly. And benign doesn’t mean harmless; benign tumors can cause serious problems such as paralysis, seizures and personality changes depending on which parts of the brain they affect.