Category: Research and Publications

Researchers at WashU Medicine’s Center for Cardiovascular Research have discovered that specialized immune cells from the spleen play a critical role in healing the heart after a heart attack. The study, led by Sumanth Prabhu, MD, Division Chief and director of the Prabhu Lab, identifies a unique population of macrophages—immune cells that clean up cellular debris—that travel […]

Researchers at the WashU Medicine  Sah Lab in the Center for Cardiovascular Research and their collaborators have published findings that provide a proof of concept for a  novel drug class to treat myocardial infarction and stroke. Rajan Sah, MD, PhD, a professor of medicine in the cardiovascular division, worked with multiple teams that collaborated to observe and describe a […]

Most cancer genome studies have focused on mutations in the tumor itself and how such gene variants allow a tumor to grow unchecked. A new study, led by researchers at Washington University School of Medicine in St. Louis, takes a deep dive into inherited cancer mutations measured in a healthy blood sample and reports how […]

William H. McCoy IV, MD, PhD, Assistant Professor in the Division of Dermatology at Washington University School of Medicine in St. Louis, recently published a manuscript in the Journal of Investigative Dermatology (JID).

Researchers at the WashU Medicine  Sah Lab in the Center for Cardiovascular Research and their collaborators have published findings that provide a proof of concept for a  novel drug class to treat myocardial infarction and stroke. Rajan Sah, MD, PhD, a professor of medicine in the cardiovascular division, worked with multiple teams that collaborated to observe and describe a […]

Bryce E. Montané, MD, Assistant Professor and Brian F. Gage, MD,MSc, Professor of Medicine, WashU Medicine Division of General Medicine and Geriatrics, led an interdisciplinary team to review trials of ablation of atrial fibrillation.  They found that compared with medical therapy, catheter ablation reduced the relative risk for ischemic stroke by 37%, for death by […]

A new study from Washington University School of Medicine in St. Louis identifies a possible way to slow or block progression of age-related macular degeneration, a leading cause of blindness in people over age 50. The WashU Medicine researchers and their international collaborators implicated problems with cholesterol metabolism in this type of vision loss, perhaps […]

Study Finds That Testosterone Gel Use in Women Recovering from Hip Fracture Does Not Improve Outcomes Compared to Supervised Exercise Alone Results from a recent multi-center, randomized, controlled trial demonstrate that testosterone gel does not improve physical function compared to exercise alone in older women recovering from a hip fracture. The STEP-HI study was published […]

In January, Marina Litvin, MD, an Associate Professor of Medicine at WashU Medicine’s Division of Endocrinology, Metabolism and Lipid Research, published an editorial titled “Metabolic Syndrome in the Post-ETI Era” in the Journal of Cystic Fibrosis.

Researchers at WashU Medicine and the University of Texas Medical Branch have uncovered that drug resistance in Fasciola hepatica, a parasitic liver fluke that infects both humans and livestock, has emerged independently in different regions of the world. The findings, published in Nature Communications, are based on the analysis of more than 300 adult liver fluke samples […]

Nathaniel Hogrebe, PhD has always had an interest in science, and now, as a junior faculty member in the Millman Lab, he has steadily built a career as a leader in diabetes research, working closely with Dr. Millman to pioneer cutting-edge research in stem cell-derived islets (SC-islets).

Sina Jasim, MD, MPH; Allan Golding, MD; David Bimston, MD; Yang Chen, PhD; Ruochen Jiang, PhD; Yangyang Hao, PhD; Jing Huang, PhD; Joshua P. Klopper, MD; Richard T. Kloos, MD; and Taylor C. Brown, MD, MHS had their research article titled “Cytologic and Molecular Assessment of Isthmus Thyroid Nodules and Carcinomas,” published online ahead of print in the journal Thyroid. 

Comparative Safety of Different Antibiotic Regimens for the Treatment of Outpatient Community-Acquired Pneumonia Among Otherwise Healthy Adults  Anne Mobley Butler, PhD, Assistant Professor of Medicine, WashU Medicine – Division of Infectious Diseases, was recently shared in the IDSA daily news briefing. IDSA Daily News Briefing is written and distributed by the editors of Bulletin Healthcare, as […]

Health care-associated infections (HAIs) cause significant morbidity and mortality, but little is known about structural factors affecting race and rurality. Katelin B. Nickel, MPH, Sr. Programmer Analyst, WashU Medicine Division of Infectious Diseases along with  Hannah Kinzer, MPH; Anne M. Butler, PhD, MS; Karen E. Joynt Maddox, MD, MPH; Victoria J. Fraser, MD, Adolphus Busch Professor of Medicine and Chair of the Department of Medicine; Jason P. Burnham, MD, […]

There’s a groundbreaking treatment being developed at WashU Medicine for women with an extremely aggressive form of breast cancer. A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors

Thomas Brett, PhD, Associate Professor of Medicine, Associate Professor of Cell Biology and Physiology, Associate Professor of Biochemistry and Molecular Biophysics, WashU Medicine Division of Pulmonary & Critical Care Medicine, Jen Alexander-Brett, MD, PhD, Assistant Professor of Medicine, WashU Medicine Division of Pulmonary and Critical Care Medicine, Daisy Leung, PhD, Professor, Departments of Medicine, Pathology […]

A recent study led by Beth Prusaczyk, PhD, MSW, Assistant Professor of Medicine in the Division of General Medicine & Geriatrics, looks at how barriers to healthcare social service utilization increases for rural area-based older adults who use drugs.

Each colored stripe in the image above represents a unique virus particle, with the width of each stripe reflecting the number of copies, in a hamster infected with SARS-CoV-2, the virus that causes COVID-19. Jacco Boon, PhD, a professor of medicine in the Division of Infectious Diseases, and colleagues have developed a tool to study […]

Brian Gage, MD, MSc, Professor of Medicine in the Division of General Medicine & Geriatrics, research on mycophenolic acid in lung transplant recipients has been published in the Journal of Heart and Lung Transplantation.

The first study to assess how weight-loss drugs affect the whole of human health has discovered an “eye-opening” impact on the body, researchers say.

Researchers are working with industry toward a clinical trial for blood cancer patients Two new studies led by researchers at Washington University School of Medicine in St. Louis have identified a possible way to block the progression of several forms of blood cancer using a drug already in clinical trials against breast cancer.

Off-the-shelf CAR-natural killer cells could expand accessibility, reduce cost of cell-based cancer therapies

Jeffrey P. Henderson, MD, PhD, FIDSA, Professor of Medicine and Molecular Microbiology, at WashU Division of Infectious Diseases, was recently published in ASM Journals with new insights into the development of a metabolome-based respiratory infection prognostic during COVID-19. Henderson highlights that the supportive environment at WashU Medicine played a crucial role in making this work possible, […]

In March, Samantha Adamson, MD, PhD; Sangeeta Adak, PhD; Max C. Petersen, MD, PhD; Dustin Higgins, DO; Larry D. Spears, PhD; Rong Mei Zhang, MD; Andrea Cedeno, MD; Alexis McKee, MD, CDCES; Aswathi Kumar, MD; Sudhir M. Singh, MD;  Fong-Fu Hsu, PhD; Janet B. McGill, MD, MA, FACP; and Clay F. Semenkovich, MD had their article titled “Decreased sarcoplasmic reticulum phospholipids in human skeletal muscle are associated with metabolic […]

The brightest minds solving brain cancer’s toughest challenges. Brain tumors are among the most challenging cancers to effectively treat. Depending on the tumor’s location, surgery can interfere with cognitive function, movement or language, and surgery often is not the solution because the tumor cells are invasive and intertwined with normal brain cells. Additionally, the brain’s […]

Clinical trial indicates safety, fewer cases of life-threatening graft-versus-host disease than expected Adding a new drug to standard care for stem cell transplant recipients may reduce a life-threatening side effect, according to an early-stage clinical trial conducted at Washington University School of Medicine in St. Louis. The trial showed that patients being treated for various […]

A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors. Conducted at Washington University School of Medicine in St. Louis with a therapy designed by Washington University researchers, the trial is the first to report results for this type of vaccine — known […]

A polypill is suggested containing all 4 classes of guideline-directed medical therapy for heart failure Justin Chen, MD, First Year Cardiology Fellow, First Author along with Anubha Agarwal, MD, MSc, Assistant Professor of Medicine, Co-Director, Program in Global Cardiovascular Health, WashU Medicine Cardiovascular Division, Senior Author, have published in Circulation: Cardiovascular Quality and Outcomes. The […]

A new analysis led by researchers at Washington University School of Medicine in St. Louis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells — and the cells of a tumor’s surrounding environment — are organized, in 3D, and how that organization changes […]

The Center for Dissemination and Implementation announces the launch of a new Midwest Developmental Center for AIDS Research (D-CFAR) in Missouri, which brings together researchers from across the translational spectrum to address the HIV epidemic. This D-CFAR is part of a national network of 20 NIH-funded centers, and it is the first of its kind […]

A new research network initiative is being launched by Sunny Lin, PhD, MS, in the Division of General Medicine & Geriatrics – Research Unit.