Category: Research

Further studies underway to determine extent of clinical benefits

Study indicates timing of chemotherapy could improve treatment for deadly brain cancer

Independent of cholesterol, gene variants raise risk of heart disease, diabetes, high blood pressure

Virus-based therapy may unlock potential of immunotherapy for glioblastoma

Sequencing results returned in a few days; costs similar to conventional testing

Researchers seek participants with diabetes that doesn’t fit type 1 or type 2 categories

Washington University researchers part of team probing inflammation after heart attack

Glioblastoma study could lead to new treatments, including better immunotherapies

New grant to fund research into drugs that showed promise in small study of people with Crohn’s disease

Drugs that trigger alarm could lead to new HIV therapies

Findings could help improve treatment decisions

Medical school labs pivot to fight a common enemy

2 drugs targeting cancer cells’ energy source potentially could replace toxic chemo in osteosarcoma

Mice expressing increased levels of protein develop advanced liver disease

Measuring mitochondrial DNA could predict who will need ICU care, intubation

Newly identified pathway explains why antihistamine drugs often don’t work to control severe itch

Bacteria change surface of human intestine to benefit themselves

Discovery of receptor, generation of decoy could help contain outbreaks of Venezuelan equine encephalitis virus

Washington University School of Medicine in St. Louis is a testing site for the Janssen Pharmaceutical Companies of Johnson & Johnson’s phase 3 clinical research study, called the ENSEMBLE trial, to evaluate the safety and efficacy of Janssen’s investigational COVID-19 vaccine candidate, JNJ-78436735, also known as Ad26.COV2.S.

The communities of bacteria that live in our digestive tracts help digest food and produce vitamins, protect against pathogens, and promote the healthy functioning of our immune system. But alongside gut bacteria thrives a vast community of viruses, and we know little about their impact on health and disease.

Flu season comes around like clockwork every year, and sooner or later everyone gets infected. The annual flu shot is a key part of public health efforts to control the flu, but the vaccine’s effectiveness is notoriously poor, falling somewhere from 40% to 60% in a typical year.

Flu season comes around like clockwork every year, and sooner or later everyone gets infected. The annual flu shot is a key part of public health efforts to control the flu, but the vaccine’s effectiveness is notoriously poor, falling somewhere from 40% to 60% in a typical year. A growing body of evidence suggests that […]

Scientists at Washington University School of Medicine in St. Louis have developed a vaccine that targets the SARS-CoV-2 virus, can be given in one dose via the nose and is effective in preventing infection in mice susceptible to the novel coronavirus. The investigators next plan to test the vaccine in nonhuman primates and humans to […]

Gastric bypass surgery is the most effective therapy to treat or reverse type 2 diabetes in severely obese patients. Many achieve remission of diabetes following surgery and no longer require diabetes medications. This observation has led to the theory that gastric bypass surgery has unique, weight loss-independent effects in treating diabetes, but this has remained […]

Many children treated for childhood malnutrition in developing countries never fully recover. They suffer from stunted growth, immune system dysfunction and poor cognitive development that typically cause long-term health issues into adulthood.

Some of the most promising advances in cancer treatment have centered on immunotherapies that rev up a patient’s immune system to attack cancer. But immunotherapies don’t work in all patients, and researchers have been searching for ways to increase their effectiveness.

Chikungunya virus, once confined to the Eastern Hemisphere, has infected millions of people in the Americas since 2013, when mosquitoes carrying the virus were discovered in the Caribbean. About half of all people infected with chikungunya virus never show symptoms, while some develop fever and joint pain that lasts about a week, and 10% to […]

A major U.S. study reveals large gaps between urban and rural patients in quality of care received after a stroke and rates of survival. In more rural areas, the ability of hospitals to deliver advanced stroke care is lower and mortality rates substantially higher, the research shows.