“Hexamerization: explaining the original sin of IgG-mediated complement activation in acute lung injury”
Hrishikesh S Kulkarni, MD, MSCI, Associate Professor of Medicine and Molecular Microbiology; Associate Program Director for Research, Division of Pulmonary and Critical Care Medicine, recently was published in the Journal of Clinical Investigation (JCI).
The editorial in the Journal of Clinical Investigation highlights the work done by Looney et al. on how IgG hexamerization serves as a key pathophysiological mechanism in alloimmune lung injury models and is mediated through the classical pathway of complement activation. This discovery has implications for transfusion-related acute lung injury, autoimmune disorders and lung transplantation. Additionally, the manuscript summarizes novel methods to potentially prevent this hexamerization and thus, develop new therapies for antibody-mediated lung injury.
