Response to updated vaccine is shaped by earlier vaccines yet generates broadly neutralizing antibodies
Repeat COVID-19 vaccinations elicit antibodies that neutralize variants, other viruses (Links to an external site)
Category: Research and Publications
World Hypertension Day
May 17, 2024: “Measure Your Blood Pressure Accurately, Control It, Live Longer” The important World Hypertension Day was first held on 14 May 2005, and has since become an ever-expanding yearly event. This brief provides an update on high-impact hypertension-related research in Nigeria supported by Washington University. Hypertension, also known as raised blood pressure, affects […]
Disrupting Type One Diabetes
(interview with Dr. Jeff Millman) Tell Us About Yourself My name is Jeff Millman, PhD, and I am a bioengineer within the Division of Endocrinology, Metabolism and Lipid Research in the Department of Medicine here at WashU. My bioengineering expertise uniquely positions me to pioneer research in a laboratory environment, with a steadfast commitment to […]
Can AI be applied to revolutionize healthcare and medical outcomes? (Links to an external site)
This past September, I had the opportunity to participate in an eye-opening event across the river from my hometown of Boston, MA. The event was a discussion of AI in medicine held on the campus of Harvard University. During the discussion, a senior faculty leader at Harvard Medical School commented to the effect that research […]
Urano joins podcast to share all you need to know about Wolfram syndrome (Links to an external site)
Recently, Fumihiko Urano, MD, PhD joined “It Happened to Me” podcast hosts Cathy Gildenhorn and Beth Glassman to discuss Wolfram syndrome and his ongoing research. Dr. Urano is the director of the Wolfram Syndrome International Registry & Clinical Study and the doctor of Cathy, who has a variant of the disease.
Dr. Jeffrey Miner’s Research Group Lands KI Journal Cover (Links to an external site)
Congratulations to the research group headed by Jeffrey Miner, PhD, on their recent publication that landed the cover of Kidney International. The colorful cover photograph, illustrating paraffin immunofluorescence of different collagen IV chains, is a figure from their article “Quantitative assessment of glomerular basement membrane (GBM) collagen IV α chains in paraffin sections from patients with focal segmental glomerulosclerosis […]
High-Dimensional Analyses Reveal IL-15 Enhances Prostate Cancer Immunotherapy
Prostate cancer cellular immunotherapy Russell Pachynski, MD, Associate Professor of Medicine, Division of Oncology, Director of Genitourinary (GU) Oncology Research, Washington University School of Medicine in St. Louis, published a paper in Cancer Immunology Research (“High dimensional analyses reveal activation of lymphocyte subsets and reversal of immunoresistance by cytokine-enhanced cellular vaccine therapy in prostate cancer”) […]
HIV Clinicians Represent Critical Point of Access for Treatment of Substance Use
Aditi Ramakrishnan, MD MSc, Assistant Professor in the Division of Infectious Diseases and Department of Medicine at the Washington University in St. Louis School of Medicine, had a first-author publication in Journal of Acquired Immune Deficiency Syndrome (JAIDS), a premier infectious diseases journal, describing the substance use treatment engagement among women with HIV in the […]
New research shows urgency to act on Nigeria’s trans fat elimination policy
Significantly reducing trans fat levels in the Nigerian food supply could prevent approximately 10,000 heart disease deaths and save 90 million USD (12 billion Naira, ₦) in healthcare costs over a decade. New findings by The George Institute for Global Health on the health and economic benefits of enacting the country’s trans fat elimination policy […]
Thakker Coauthors Research Letter in JACC (Links to an external site)
Dr. Prashanth Thakker, Assistant Professor of Medicine and Associate Director of Program Development in the Cardiovascular Fellowship program was coauthor of a research letter published in the Journal of the American College of Cardiology titled “A Leadership Program to Support Career Development of Cardiovascular Chief Fellows”.
Artificial Intelligence for Cardiovascular Care
Thomas M. Maddox, MD, MSc, Professor of Medicine, Cardiovascular Division at WashU Medicine, and colleagues recently published two articles outlining the current opportunities for AI to impact cardiovascular care. These articles highlight how AI is poised to affect almost every aspect of cardiovascular care. ” says Maddox. “Our group hopes that this work helps prepare […]
ACC Updates HFrEF Decision Pathway, Reinforcing the Four Pillars of Therapy
The document also strengthens advice regarding which medications should be started in all patients Thomas M. Maddox, MD, MSc, Professor of Medicine in the Cardiovascular Division at WashU Medicine, and colleagues recently published an Expert Consensus Decision Pathway (ECDP) for the many decisions required in the management and treatment of patients with heart failure with […]
McNerney and Jasim discuss the long-term endocrine effects of cancer treatment (Links to an external site)
On October 10, 2023, Kyle P. McNerney, MD of the Department of Pediatrics at Washington University School of Medicine and Sina Jasim, MD of the Division of Endocrinology, Metabolism and Lipid Research, had their book chapter titled “Long-Term Effects of Cancer Treatment” published in Familial Endocrine Cancer Syndromes: Navigating the Transition of Care for Pediatric and Adolescent Patients.
Combining multiple meds into a single pill reduces cardiovascular deaths (Links to an external site)
‘Polypills’ recommended to reduce heart attacks, strokes but have been slow to gain favor
Some sarcoma patients improve with T cell immunotherapy (Links to an external site)
Strategy effective against some rare, aggressive sarcomas with no other treatment options A clinical trial led by researchers at Washington University School of Medicine in St. Louis has shown that a T cell immunotherapy — in which the patients’ own T cells are genetically modified to attack and kill cancer cells — is effective in […]
COVID Linked to Lower IQ, Poor Memory and Other Negative Impacts on Brain Health (Links to an external site)
“COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level,” clinical epidemiologist Ziyad Al-Aly said
Mahjoub Lab Celebrates Recent Publications on Critical Role of Centrosomes in Kidney Development and Function (Links to an external site)
Congratulations to the research team of the Mahjoub Laboratory, who are celebrating their multiple recent publications, one of which landed the cover of the journal JCI Insight.
Civitelli Lab Published in JCI Insight (Links to an external site)
In a recent publication in JCI Insight, researchers from the Civitelli Lab unveil the pivotal role of connexin43 within mesenchymal lineage cells, shedding light on its influence in regulating body adiposity and energy metabolism in mice.
Powers Carson and Arora discuss negative correlations between BMI and glycated albumin (Links to an external site)
In October of 2023, Jennifer Powers Carson, PhD and colleague, Jyoti Arora, MS of the Washington University School of Medicine, Center for Biostatistics and Data Science, had their work published by Clinical Biochemistry. The article was titled, “Glycated serum proteins and albumin but not glycated albumin show negative correlation with BMI in an overweight/obese, diabetic population from the United States.”
Quader Publishes Article on Radiation Exposure to Echocardiographers and Sonographers (Links to an external site)
Dr. Nishath Quader, Associate Professor of Medicine in the Cardiovascular Division, recently was among the authors of a paper highlighting the risks of radiation exposure to medical providers working on cardiovascular imaging.
AI may predict spread of lung cancer to brain (Links to an external site)
Method may inform personalized cancer treatments Physicians treating patients with early-stage lung cancer face a conundrum: choosing potentially helpful yet toxic therapies such as chemotherapy, radiation or immunotherapy to knock out the cancer and lessen the risk of it spreading to the brain, or waiting to see if lung surgery alone proves sufficient. When up […]
WashU Medicine rises to No. 2 in nation in NIH research funding (Links to an external site)
Ranking reflects success as thriving hub of scientific excellence, medical innovation In the realm of biomedical research, securing funding is a testament to an institution’s record of scientific accomplishments and potential for further advances to improve human health. In 2023, Washington University School of Medicine in St. Louis received the second-highest amount of funding from […]
Dr. David DeNardo Explores How the Tumor Microenvironment Affects Immune Responses to Cancer (Links to an external site)
David DeNardo, Ph.D., is a Professor of Medicine and Co-Director of the Tumor Immunology Program at the Washington University St. Louis, School of Medicine. His research team is working to understand why responses to cancer immunotherapy vary among patients. In studying and uncovering mechanisms of cancer immunology, Dr. DeNardo aims to identify strategies that can […]
Brain tumors: Fighting with targeted tools (Links to an external site)
Whether malignant or benign, a brain tumor is life-altering. Malignant tumors can spread and become deadly. And benign doesn’t mean harmless; benign tumors can cause serious problems such as paralysis, seizures and personality changes depending on which parts of the brain they affect.
Husaini Piece Featured as ACC Editor’s Pick (Links to an external site)
A piece co-written by Assistant Professor of Medicine and Director of the Washington University Sports Cardiology program, Dr. Mustafa Husaini, was highlighted on the front page of the American Academy of Cardiology website as an Editor’s Pick.