Raja Dandamudi, MD, an assistant professor of pediatrics, Vikas Dharnidharka, MD, a professor of pediatrics, and Tarek Alhamad, MD, a professor of medicine at Washington University School of Medicine in St. Louis, contributed to a large study that identified a novel way of detecting signs of organ rejection. The international team found that DNA shed from dying […]
Two studies from Washington University School of Medicine in St. Louis focused on breast cancer and pancreatic cancer suggest that specific types of senescent cells — cells that have stopped dividing and drive inflammation — may play important roles in suppressing the immune system and allowing such tumors to grow unchecked.
The Society of Hospital Medicine has several publications, including their monthly newsletter, ‘The Hospitalist.’ For the month of August 2024, Dr. Mark Williams was featured on the cover of the newsletter, and was interviewed for an article titled, “Managing the Long-term Physical Effects of Being a Hospitalist.”
Study in hamsters indicates vaccines targeting nose, mouth may be key to controlling spread of respiratory infections
Marlie Maestas, a fifth-year graduate student in the Millman Lab, recently published her first first-authorship in Nature Communications. The study, titled Identification of unique cell type responses in pancreatic islets to stress, detailed the responses of different pancreatic islet cell types to endoplasmic reticulum and inflammatory stress.
Anuja Java, MD, Associate Professor of Medicine, Director, Kidney Transplant John Cochran VA Medical Center, Division of Nephrology, Washington University School of Medicine recently had two articles published in Science Direct. Thrombotic Microangiopathies and the Kidney Both articles delve into defining current understanding of the pathophysiological mechanisms underlying Thrombotic Microangiopathies (TMAs). TMA is a multisystem […]
Pretransplant desensitization of donor-specific anti-HLA antibodies with plasmapheresis and immunoglobulin produces equivalent outcomes to patients with no donor specific antibodies in haploidentical hematopoietic cell transplant Hunter Cassidy Cochran, MD, Hematology-Oncology Fellow, was recently published in Leukemia & Lymphoma. In many hematologic malignancies, hematopoietic cell transplant (HCT) is the only curative option. The likelihood of finding […]
DOLF investigators are beginning a follow-up study on the efficacy of a new combination treatment for lymphatic filariasis (LF) and onchocerciasis in the Akoupé district of Côte d’Ivoire. This study began July 4th and builds upon a large-scale community survey sponsored by Medicines Development for Global Health (MDGH).
Researchers in the Department of Medicine reveal new ways that human natural killer (NK) cells are rewired by signals through cytokine receptors to generate a memory-like program. In a report published in Science Immunology, co-first authors Jennifer Foltz, PhD, and Jennifer Tran build on prior work from senior author Todd Fehniger, MD, PhD, WashU Division […]
St. Louis-based center unites scientists, public health experts, nonprofits to fight virus
“Heavy and healthy” can be a rare or common condition. But either way it may signal that some excess weight is just fine.
Associate Professor of Medicine and Associate Director of the Wash U Hypertrophic Cardiomyopathy Center, Dr. Sharon Cresci is Vice-Chair on a new statement published this week in the journal Circulation on behalf of the American Heart Association.
Center will support new collaborations, infrastructure to accelerate precision medicine
“Hexamerization: explaining the original sin of IgG-mediated complement activation in acute lung injury” Hrishikesh S Kulkarni, MD, MSCI, Associate Professor of Medicine and Molecular Microbiology; Associate Program Director for Research, Division of Pulmonary and Critical Care Medicine, recently was published in the Journal of Clinical Investigation (JCI). The editorial in the Journal of Clinical Investigation […]
Congratulations to first-year fellow Susrutha Puthanmadhom Narayanan, MBBS, who presented her research at ASCO 2024 this past weekend entitled, “Transcriptomic Analysis of cAMP/PKA/CREB Signaling in Invasive Lobular Breast Cancer”.
Three dimensional images of human pancreatic islet cells provide an unprecedented view of the enigmatic primary cilia Jing Hughes, MD, Assistant Professor of Medicine, Division of Endocrinology, Metabolism & Lipid Research recent paper, “Scanning electron microscopy of human islet cilia” was published in Proceedings of the National Academy of Sciences (PNAS) and follow-up article, “Immuno-scanning […]
Artificial intelligence—the next wave of technology— is emerging in many ways in medical practices and health systems in the St. Louis area.
Genetically engineered B cells could produce super-antibodies to HIV
“Integration of Clinical Trial Development in Hematology-Oncology Fellowship Training” describes the Clinical Trial Development Program initiated at Washington University School of Medicine in 2002. This program was developed as a hands-on learning experience for Hematology-Oncology fellow in the design, implementation and publication of clinical trials and is led by Dr. Lee Ratner, Associate Program Director […]
Study also shows that patients hospitalized within 30 days after infection face 29% higher death risk in 3rd year compared with those not infected
Max Petersen, MD, PhD, Instructor in Medicine, Division of Endocrinology, Metabolism & Lipid Research, recently published a paper, Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity, in Cell Metabolism. The senior author of the study was Samuel Klein, MD, the William Danforth Professor of Medicine, and Chief of the Division of Nutritional Science & […]
Response to updated vaccine is shaped by earlier vaccines yet generates broadly neutralizing antibodies
May 17, 2024: “Measure Your Blood Pressure Accurately, Control It, Live Longer” The important World Hypertension Day was first held on 14 May 2005, and has since become an ever-expanding yearly event. This brief provides an update on high-impact hypertension-related research in Nigeria supported by Washington University. Hypertension, also known as raised blood pressure, affects […]
(interview with Dr. Jeff Millman) Tell Us About Yourself My name is Jeff Millman, PhD, and I am a bioengineer within the Division of Endocrinology, Metabolism and Lipid Research in the Department of Medicine here at WashU. My bioengineering expertise uniquely positions me to pioneer research in a laboratory environment, with a steadfast commitment to […]
This past September, I had the opportunity to participate in an eye-opening event across the river from my hometown of Boston, MA. The event was a discussion of AI in medicine held on the campus of Harvard University. During the discussion, a senior faculty leader at Harvard Medical School commented to the effect that research […]
Recently, Fumihiko Urano, MD, PhD joined “It Happened to Me” podcast hosts Cathy Gildenhorn and Beth Glassman to discuss Wolfram syndrome and his ongoing research. Dr. Urano is the director of the Wolfram Syndrome International Registry & Clinical Study and the doctor of Cathy, who has a variant of the disease.
Congratulations to the research group headed by Jeffrey Miner, PhD, on their recent publication that landed the cover of Kidney International. The colorful cover photograph, illustrating paraffin immunofluorescence of different collagen IV chains, is a figure from their article “Quantitative assessment of glomerular basement membrane (GBM) collagen IV α chains in paraffin sections from patients with focal segmental glomerulosclerosis […]
Prostate cancer cellular immunotherapy Russell Pachynski, MD, Associate Professor of Medicine, Division of Oncology, Director of Genitourinary (GU) Oncology Research, Washington University School of Medicine in St. Louis, published a paper in Cancer Immunology Research (“High dimensional analyses reveal activation of lymphocyte subsets and reversal of immunoresistance by cytokine-enhanced cellular vaccine therapy in prostate cancer”) […]
Aditi Ramakrishnan, MD MSc, Assistant Professor in the Division of Infectious Diseases and Department of Medicine at the Washington University in St. Louis School of Medicine, had a first-author publication in Journal of Acquired Immune Deficiency Syndrome (JAIDS), a premier infectious diseases journal, describing the substance use treatment engagement among women with HIV in the […]
Significantly reducing trans fat levels in the Nigerian food supply could prevent approximately 10,000 heart disease deaths and save 90 million USD (12 billion Naira, ₦) in healthcare costs over a decade. New findings by The George Institute for Global Health on the health and economic benefits of enacting the country’s trans fat elimination policy […]
Dr. Prashanth Thakker, Assistant Professor of Medicine and Associate Director of Program Development in the Cardiovascular Fellowship program was coauthor of a research letter published in the Journal of the American College of Cardiology titled “A Leadership Program to Support Career Development of Cardiovascular Chief Fellows”.
Thomas M. Maddox, MD, MSc, Professor of Medicine, Cardiovascular Division at WashU Medicine, and colleagues recently published two articles outlining the current opportunities for AI to impact cardiovascular care. These articles highlight how AI is poised to affect almost every aspect of cardiovascular care. ” says Maddox. “Our group hopes that this work helps prepare […]
The document also strengthens advice regarding which medications should be started in all patients Thomas M. Maddox, MD, MSc, Professor of Medicine in the Cardiovascular Division at WashU Medicine, and colleagues recently published an Expert Consensus Decision Pathway (ECDP) for the many decisions required in the management and treatment of patients with heart failure with […]
On October 10, 2023, Kyle P. McNerney, MD of the Department of Pediatrics at Washington University School of Medicine and Sina Jasim, MD of the Division of Endocrinology, Metabolism and Lipid Research, had their book chapter titled “Long-Term Effects of Cancer Treatment” published in Familial Endocrine Cancer Syndromes: Navigating the Transition of Care for Pediatric and Adolescent Patients.
‘Polypills’ recommended to reduce heart attacks, strokes but have been slow to gain favor
Strategy effective against some rare, aggressive sarcomas with no other treatment options A clinical trial led by researchers at Washington University School of Medicine in St. Louis has shown that a T cell immunotherapy — in which the patients’ own T cells are genetically modified to attack and kill cancer cells — is effective in […]
“COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level,” clinical epidemiologist Ziyad Al-Aly said
Congratulations to the research team of the Mahjoub Laboratory, who are celebrating their multiple recent publications, one of which landed the cover of the journal JCI Insight.
In a recent publication in JCI Insight, researchers from the Civitelli Lab unveil the pivotal role of connexin43 within mesenchymal lineage cells, shedding light on its influence in regulating body adiposity and energy metabolism in mice.
In October of 2023, Jennifer Powers Carson, PhD and colleague, Jyoti Arora, MS of the Washington University School of Medicine, Center for Biostatistics and Data Science, had their work published by Clinical Biochemistry. The article was titled, “Glycated serum proteins and albumin but not glycated albumin show negative correlation with BMI in an overweight/obese, diabetic population from the United States.”
Dr. Nishath Quader, Associate Professor of Medicine in the Cardiovascular Division, recently was among the authors of a paper highlighting the risks of radiation exposure to medical providers working on cardiovascular imaging.
Method may inform personalized cancer treatments Physicians treating patients with early-stage lung cancer face a conundrum: choosing potentially helpful yet toxic therapies such as chemotherapy, radiation or immunotherapy to knock out the cancer and lessen the risk of it spreading to the brain, or waiting to see if lung surgery alone proves sufficient. When up […]
Ranking reflects success as thriving hub of scientific excellence, medical innovation In the realm of biomedical research, securing funding is a testament to an institution’s record of scientific accomplishments and potential for further advances to improve human health. In 2023, Washington University School of Medicine in St. Louis received the second-highest amount of funding from […]
David DeNardo, Ph.D., is a Professor of Medicine and Co-Director of the Tumor Immunology Program at the Washington University St. Louis, School of Medicine. His research team is working to understand why responses to cancer immunotherapy vary among patients. In studying and uncovering mechanisms of cancer immunology, Dr. DeNardo aims to identify strategies that can […]
Whether malignant or benign, a brain tumor is life-altering. Malignant tumors can spread and become deadly. And benign doesn’t mean harmless; benign tumors can cause serious problems such as paralysis, seizures and personality changes depending on which parts of the brain they affect.
A piece co-written by Assistant Professor of Medicine and Director of the Washington University Sports Cardiology program, Dr. Mustafa Husaini, was highlighted on the front page of the American Academy of Cardiology website as an Editor’s Pick.