Welcome: Ira Hall, MD
June 1, 2014
Ira Hall, MD, associate professor of Medicine, Division of Oncology
Dr. Hall leads a research group at The Genome Institute. He is an expert in genome biology, genomic technologies and bioinformatics. His current research focuses on developing computational methods for analyzing and interpreting large-scale genomic datasets, and on using high-throughput techniques to study genome variation and human disease.
Dr. Hall’s research career has spanned the fields of genetics, epigenetics, genomics and bioinformatics. Dr. Hall received a BA from the University of California at Berkeley (1998) and a PhD from the Watson School of Biological Sciences at Cold Spring Harbor Laboratory (2003). His thesis work established the first direct link between RNA interference and chromatin-based epigenetic inheritance. As a CSHL Fellow (2003-2007), Dr. Hall’s lab used microarray technologies and mouse strain genealogies to conduct the first systematic study of DNA copy number variation hotspots. As a faculty member at the University of Virginia (2007-2014) and Washington University School of Medicine (2014-), Dr. Hall’s work has focused on understanding the causes and consequences of genome variation in mammals. His group has developed novel bioinformatic methods including software for structural variation detection (Hydra and LUMPY), DNA sequence alignment (YAHA), data integration (BEDTools), and ultra-fast clinical human genome interpretation (SpeedSeq). Recently, Dr. Hall’s lab has used genome sequencing technologies to study human disorders, tumor evolution, bacterial recombination, mouse strain variation, genome stability in induced pluripotent stem cells, and single-cell somatic mosaicism in the human brain.
Dr. Hall’s work has been featured in Science Magazine’s Breakthrough of the Year (2003 & 2007), the NIMH Director’s “Ten Best of 2013” and The Scientist (2013), and he has received several prestigious awards including the AAAS Newcomb Cleveland Prize (2003), the Burroughs Wellcome Fund Career Award (2006), the NIH Director’s New Innovator Award (2009), and the March of Dimes Basil O’Connor Research Award (2010). He has also served as an Associate Editor at Genome Research (2009-2014) and is an Associate Editor at Genes, Genome and Genetics (G3).New Faculty